Mark Eric Layton

Affiliations: 
2002 Harvard University, Cambridge, MA, United States 
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"Mark Layton"
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Matthew D. Shair grad student 2002 Harvard
 (Syntheses of (-)-longithorone A and ( )-CP-263,114.)
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Pero JE, Rossi MA, Kelly MJ, et al. (2016) Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI. Acs Medicinal Chemistry Letters. 7: 312-7
Layton ME, Reif AJ, Hartingh TJ, et al. (2016) Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis. Bioorganic & Medicinal Chemistry Letters
Layton ME, Kelly MJ, Rodzinak KJ, et al. (2011) Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists. Acs Chemical Neuroscience. 2: 352-62
Brnardic EJ, Fraley ME, Garbaccio RM, et al. (2010) 3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts. Bioorganic & Medicinal Chemistry Letters. 20: 3129-33
Lindsley CW, Barnett SF, Layton ME, et al. (2008) The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors. Current Cancer Drug Targets. 8: 7-18
Lindsley CW, Barnett SF, Yaroschak M, et al. (2007) Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors. Current Topics in Medicinal Chemistry. 7: 1349-63
Layton ME, Kelly MJ, Rodzinak KJ. (2006) Recent advances in the development of NR2B subtype-selective NMDA receptor antagonists. Current Topics in Medicinal Chemistry. 6: 697-709
Layton ME. (2005) Subtype-selective noncompetitive modulators of metabotropic glutamate receptor subtype 1 (mGluR1). Current Topics in Medicinal Chemistry. 5: 859-67
Morales CA, Layton ME, Shair MD. (2004) Synthesis of (-)-longithorone A: using organic synthesis to probe a proposed biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 12036-41
Layton ME, Morales CA, Shair MD. (2002) Biomimetic synthesis of (-)-longithorone A. Journal of the American Chemical Society. 124: 773-5
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