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Darren William Begley

Affiliations: 
2009 University of Washington, Seattle, Seattle, WA 
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"Darren Begley"
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Parents

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Gabriele Varani grad student 2009 University of Washington
 (Fragment-based drug design of novel leads for thymidylate synthase inhibition by NMR.)

Children

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Collaborators

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Timothy J. Hagen collaborator 2011-2014 Emerald Biosciences
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Publications

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Haft DH, Pierce PG, Mayclin SJ, et al. (2017) Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors. Scientific Reports. 7: 41074
Goshu GM, Ghose D, Bain JM, et al. (2015) Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents. Bioorganic & Medicinal Chemistry Letters
Baugh L, Phan I, Begley DW, et al. (2015) Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinburgh, Scotland). 95: 142-8
Moen SO, Abendroth J, Fairman JW, et al. (2014) Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1. Scientific Reports. 4: 5944
Begley DW, Fox D, Jenner D, et al. (2014) A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrobial Agents and Chemotherapy. 58: 1458-67
Begley DW, Moen SO, Pierce PG, et al. (2013) Saturation transfer difference NMR for fragment screening. Current Protocols in Chemical Biology. 5: 251-68
Zhang Z, Jakkaraju S, Blain J, et al. (2013) Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei. Bioorganic & Medicinal Chemistry Letters. 23: 6860-3
Armour BL, Barnes SR, Moen SO, et al. (2013) Multi-target parallel processing approach for gene-to-structure determination of the influenza polymerase PB2 subunit. Journal of Visualized Experiments : Jove
Baugh L, Gallagher LA, Patrapuvich R, et al. (2013) Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One. 8: e53851
Zhang Y, Edwards TE, Begley DW, et al. (2011) Structure of nitrilotriacetate monooxygenase component B from Mycobacterium thermoresistibile. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1100-5
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