R. Jeffrey Neitz

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2003 University of Michigan, Ann Arbor, Ann Arbor, MI 
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William R. Roush grad student 2003 University of Michigan
 (Total synthesis of the structure of the putative landomycin aglycone, revision of the structure and studies directed toward the synthesis of the proposed structure of the landomycin aglycone.)
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Publications

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Long T, Neitz RJ, Beasley R, et al. (2016) Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. Plos Neglected Tropical Diseases. 10: e0004356
Alverez C, Bulfer SL, Chakrasali R, et al. (2016) Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway Acs Medicinal Chemistry Letters. 7: 182-187
Neitz RJ, Bryant C, Chen S, et al. (2015) Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. Bioorganic & Medicinal Chemistry Letters. 25: 4834-7
Chimenti MS, Bulfer SL, Neitz RJ, et al. (2015) A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP. Journal of Biomolecular Screening. 20: 788-800
Alverez C, Arkin MR, Bulfer SL, et al. (2015) Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97 Acs Medicinal Chemistry Letters. 6: 1225-1230
Ng RA, Sun M, Bowers S, et al. (2013) Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 4674-9
Aubele DL, Hom RK, Adler M, et al. (2013) Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain. Chemmedchem. 8: 1295-313
Bowers S, Truong AP, Ye M, et al. (2013) Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 2743-9
Garofalo AW, Adler M, Aubele DL, et al. (2013) Novel cinnoline-based inhibitors of LRRK2 kinase activity. Bioorganic & Medicinal Chemistry Letters. 23: 71-4
Neitz RJ, Konradi AW, Sham HL, et al. (2011) Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement. Bioorganic & Medicinal Chemistry Letters. 21: 3726-9
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