Roxanne Kay Kunz

Affiliations: 
2003 University of Michigan, Ann Arbor, Ann Arbor, MI 
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William R. Roush grad student 2003 University of Michigan
 (Studies toward the total synthesis of quartromicin D(3).)
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Chen H, Lester-Zeiner D, Shi J, et al. (2015) AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer. The Journal of Pharmacology and Experimental Therapeutics. 352: 327-37
Rzasa RM, Frohn MJ, Andrews KL, et al. (2014) Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility. Bioorganic & Medicinal Chemistry. 22: 6570-85
Hu E, Chen N, Bourbeau MP, et al. (2014) Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). Journal of Medicinal Chemistry. 57: 6632-41
Nishimura N, Norman MH, Liu L, et al. (2014) Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. Journal of Medicinal Chemistry. 57: 3094-116
St Jean DJ, Ashton KS, Bartberger MD, et al. (2014) Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. Journal of Medicinal Chemistry. 57: 325-38
Hu E, Kunz RK, Chen N, et al. (2013) Design, optimization, and biological evaluation of novel keto-benzimidazoles as potent and selective inhibitors of phosphodiesterase 10A (PDE10A). Journal of Medicinal Chemistry. 56: 8781-92
Hu E, Kunz RK, Rumfelt S, et al. (2012) Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3). Bioorganic & Medicinal Chemistry Letters. 22: 6938-42
Hu E, Ma J, Biorn C, et al. (2012) Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer. Journal of Medicinal Chemistry. 55: 4776-87
Hu E, Kunz RK, Rumfelt S, et al. (2012) Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2262-5
Kunz RK, Rumfelt S, Chen N, et al. (2008) Discovery of amido-benzisoxazoles as potent c-Kit inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 5115-7
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