Dustin J. Mergott

Affiliations: 
2004 University of Michigan, Ann Arbor, Ann Arbor, MI 
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"Dustin Mergott"
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William R. Roush grad student 2004 University of Michigan
 (Total synthesis of (-)-spinosyn A.)
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Winneroski LL, Schiffler MA, Erickson JA, et al. (2015) Preparation and biological evaluation of conformationally constrained BACE1 inhibitors. Bioorganic & Medicinal Chemistry. 23: 3260-8
May PC, Willis BA, Lowe SL, et al. (2015) The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1199-210
Rincón JA, Mateos C, García-Losada P, et al. (2015) Large-scale continuous flow transformation of oximes into fused-bicyclic isoxazolidines: An example of process intensification Organic Process Research and Development. 19: 347-351
May PC, Dean RA, Lowe SL, et al. (2011) Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16507-16
Beck JP, Mergott DJ. (2010) Peptidic, Peptidomimetic, and HTS-Derived BACE Inhibitors Bace: Lead Target For Orchestrated Therapy of Alzheimer's Disease. 59-105
Mergott DJ, Zuend SJ, Jacobsen EN. (2008) Catalytic asymmetric total synthesis of (+)-yohimbine. Organic Letters. 10: 745-8
Winbush SM, Mergott DJ, Roush WR. (2008) Total synthesis of (-)-spinosyn A: examination of structural features that govern the stereoselectivity of the key transannular Diels-Alder reaction. The Journal of Organic Chemistry. 73: 1818-29
Mergott DJ, Frank SA, Roush WR. (2004) Total synthesis of (-)-spinosyn A. Proceedings of the National Academy of Sciences of the United States of America. 101: 11955-9
Mergott DJ, Frank SA, Roush WR. (2002) Application of the intramolecular vinylogous Morita-Baylis-Hillman reaction toward the synthesis of the spinosyn A tricyclic nucleus. Organic Letters. 4: 3157-60
Frank SA, Mergott DJ, Roush WR. (2002) The vinylogous intramolecular Morita-Baylis-Hillman reaction: synthesis of functionalized cyclopentenes and cyclohexenes with trialkylphosphines as nucleophilic catalysts. Journal of the American Chemical Society. 124: 2404-5
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