Christopher Joseph Leitheiser

Affiliations: 
2003 University of Virginia, Charlottesville, VA 
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"Christopher Leitheiser"
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Sidney M. Hecht grad student 2003 UVA
 (Solid phase and combinatorial synthesis of deglycobleomycins.)
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Wang B, Hansen TM, Wang T, et al. (2011) Total synthesis of phorboxazole A via de novo oxazole formation: strategy and component assembly. Journal of the American Chemical Society. 133: 1484-505
Ma Q, Xu Z, Schroeder BR, et al. (2007) Biochemical evaluation of a 108-member deglycobleomycin library: viability of a selection strategy for identifying bleomycin analogues with altered properties. Journal of the American Chemical Society. 129: 12439-52
Leitheiser CJ, Hecht SM. (2003) Solid-phase synthesis of deglycobleomycin and bleomycin. Current Opinion in Drug Discovery & Development. 6: 827-37
Rishel MJ, Thomas CJ, Tao ZF, et al. (2003) Conformationally constrained analogues of bleomycin A5. Journal of the American Chemical Society. 125: 10194-205
Leitheiser CJ, Smith KL, Rishel MJ, et al. (2003) Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library. Journal of the American Chemical Society. 125: 8218-27
Thomas CJ, Chizhov AO, Leitheiser CJ, et al. (2002) Solid-phase synthesis of bleomycin A(5) and three monosaccharide analogues: exploring the role of the carbohydrate moiety in RNA cleavage. Journal of the American Chemical Society. 124: 12926-7
Tao ZF, Leitheiser CJ, Smith KL, et al. (2002) Solid-phase synthesis of deglycobleomycins: a C-terminal tetraamine linker that permits direct evaluation of resin-bound bleomycins. Bioconjugate Chemistry. 13: 426-34
Thomas CJ, McCormick MM, Vialas C, et al. (2002) Alteration of the selectivity of DNA cleavage by a deglycobleomycin analogue containing a trithiazole moiety. Journal of the American Chemical Society. 124: 3875-84
Smith KL, Tao ZF, Hashimoto S, et al. (2002) Deglycobleomycin: solid-phase synthesis and DNA cleavage by the resin-bound ligand. Organic Letters. 4: 1079-82
Leitheiser CJ, Rishel MJ, Wu X, et al. (2000) Solid-phase synthesis of bleomycin group antibiotics. Elaboration of deglycobleomycin A(5). Organic Letters. 2: 3397-9
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