Douglas A. Lappi, Ph.D.
Affiliations: | Advanced Targeting Systems |
Area:
Toxins, ribosome-inactivating proteinsGoogle:
"Douglas Lappi"Mean distance: 39813 | S | N | B | C | P |
Parents
Sign in to add mentor| Nathan O. Kaplan | research assistant | 1973-1980 | |
| Roger Guillemin | research assistant | 1982-1984 | Salk Institute |
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Publications
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| Biro S, Shrivastav S, Yu Z, et al. (1996) Stimulation of endothelial cells by doses of basic FGF-saporin that are lethal to smooth muscle cells Drug Delivery. 3: 155-163 |
| Davol P, Beitz JG, Mohler M, et al. (1995) Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model. Cancer. 76: 79-85 |
| Lappi DA, Ying W, Barthelemy I, et al. (1994) Expression and activities of a recombinant basic fibroblast growth factor-saporin fusion protein. The Journal of Biological Chemistry. 269: 12552-8 |
| Gonzalez AM, Logan A, Ying W, et al. (1994) Fibroblast growth factor in the hypothalamic-pituitary axis: differential expression of fibroblast growth factor-2 and a high affinity receptor. Endocrinology. 134: 2289-97 |
| Ying W, Martineau D, Beitz J, et al. (1994) Anti-B16-F10 melanoma activity of a basic fibroblast growth factor-saporin mitotoxin. Cancer. 74: 848-53 |
| Casscells W, Lappi DA, Baird A. (1993) Molecular atherectomy for restenosis. Trends in Cardiovascular Medicine. 3: 235-43 |
| Lappi DA, Martineau D, Sarmientos P, et al. (1993) Characterization of a saporin mitotoxin specifically cytotoxic to cells bearing the granulocyte-macrophage colony-stimulating factor receptor. Growth Factors (Chur, Switzerland). 9: 31-9 |
| Lappi DA, Matsunami R, Martineau D, et al. (1993) Reducing the heterogeneity of chemically conjugated targeted toxins: homogeneous basic FGF-saporin. Analytical Biochemistry. 212: 446-51 |
| Casscells W, Lappi DA, Baird A. (1993) Basic FGF’s role in smooth muscle cell proliferation: A basis for molecular atherectomy Developments in Cardiovascular Medicine. 147: 227-248 |
| David T, Tassin J, Lappi DA, et al. (1992) Biphasic effect of the mitotoxin bFGF-saporin on bovine lens epithelial cell growth: effect of cell density and extracellular matrix. Journal of Cellular Physiology. 153: 483-90 |