Christopher Bigge

Affiliations: 
1980-1982 Chemistry Columbia University, New York, NY 
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"Christopher Bigge"
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Casimiro-Garcia A, Heemstra RJ, Bigge CF, et al. (2013) Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ. Bioorganic & Medicinal Chemistry Letters. 23: 767-72
Casimiro-Garcia A, Filzen GF, Flynn D, et al. (2011) Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ. Journal of Medicinal Chemistry. 54: 4219-33
Casimiro-Garcia A, Bigge CF, Davis JA, et al. (2009) Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists. Bioorganic & Medicinal Chemistry. 17: 7113-25
Chen H, Zientek M, Jalaie M, et al. (2009) Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes. Chemical Research in Toxicology. 22: 1603-12
Van Huis CA, Casimiro-Garcia A, Bigge CF, et al. (2009) Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action. Bioorganic & Medicinal Chemistry. 17: 2501-11
Casimiro-Garcia A, Bigge CF, Davis JA, et al. (2008) Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies. Bioorganic & Medicinal Chemistry. 16: 4883-907
Chen H, Zhang Y, Edmunds J, et al. (2008) Bioactivation of a dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide) scaffold to a putative p-chlorophenyl isocyanate in rat liver microsomes and in vivo in rats. Chemical Research in Toxicology. 21: 1095-106
Kohrt JT, Bigge CF, Bryant JW, et al. (2007) The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor. Chemical Biology & Drug Design. 70: 100-12
Van Huis CA, Bigge CF, Casimiro-Garcia A, et al. (2007) Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors. Chemical Biology & Drug Design. 69: 444-50
Kohrt JT, Filipski KJ, Cody WL, et al. (2006) The discovery of glycine and related amino acid-based factor Xa inhibitors. Bioorganic & Medicinal Chemistry. 14: 4379-92
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