Kent S. Gates, Ph.D.

1993- Chemistry University of Missouri, Columbia, MO 
Medicinal Chemistry
"Kent Gates"
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Laciak AR, Korasick DA, Wyatt JW, et al. (2019) Structural and Biochemical Consequences of Pyridoxine-Dependent Epilepsy Mutations That Target the Aldehyde Binding Site of Aldehyde Dehydrogenase ALDH7A1. The Febs Journal
Nejad MI, Price NE, Haldar T, et al. (2019) Interstrand DNA Cross-Links Derived from Reaction of a 2-Aminopurine Residue with an Abasic Site. Acs Chemical Biology
Nejad MI, Guo X, Housh K, et al. (2019) Preparation and Purification of Oligodeoxynucleotide Duplexes Containing a Site-Specific, Reduced, Chemically Stable Covalent Interstrand Cross-Link Between a Guanine Residue and an Abasic Site. Methods in Molecular Biology (Clifton, N.J.). 1973: 163-175
Shen X, Laber CH, Sarkar U, et al. (2018) Exploiting the inherent photophysical properties of the major tirapazamine metabolite in the development of profluorescent substrates for enzymes that catalyze the bioreductive activation of hypoxia-selective anticancer prodrugs. The Journal of Organic Chemistry
Korasick D, Wyatt J, Luo M, et al. (2017) Importance of the C-terminus of ALDH7A1 for Oligomerization and Catalytic Activity. Biochemistry
Wang Y, Tian K, Shi R, et al. (2017) Nanolock-Nanopore Facilitated Digital Diagnostics of Cancer Driver Mutation in Tumor Tissue. Acs Sensors. 2: 975-981
Yang Z, Price NE, Johnson KM, et al. (2017) Interstrand cross-links arising from strand breaks at true abasic sites in duplex DNA. Nucleic Acids Research
Sarkar U, Hillebrand R, Johnson KM, et al. (2017) Application of Suzuki-Miyaura and Buchwald-Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine. Journal of Heterocyclic Chemistry. 54: 155-160
Price NE, Li L, Gates KS, et al. (2017) Replication and repair of a reduced 2΄-deoxyguanosine-abasic site interstrand cross-link in human cells. Nucleic Acids Research
Punthasee P, Laciak AR, Cummings AH, et al. (2017) Covalent allosteric inactivation of PTP1B by an inhibitor-electrophile conjugate. Biochemistry
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