Yih-Shyan Lin

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2014 Chemistry McGill University, Montreal, QC, Canada 
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"Yih-Shyan Lin"
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Park J, Rodionov D, De Schutter JW, et al. (2017) Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. Plos One. 12: e0186447
Gritzalis D, Park J, Chiu W, et al. (2015) Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. Bioorganic & Medicinal Chemistry Letters. 25: 1117-23
Lacbay CM, Mancuso J, Lin YS, et al. (2014) Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase. Journal of Medicinal Chemistry. 57: 7435-49
De Schutter JW, Park J, Leung CY, et al. (2014) Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. Journal of Medicinal Chemistry. 57: 5764-76
Park J, Lin YS, Tsantrizos YS, et al. (2014) Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallographica. Section F, Structural Biology Communications. 70: 299-304
Park J, Leung C, Lin Y, et al. (2014) Crystal structures of hFPPS in complex with novel anticancer drug leads Acta Crystallographica Section a Foundations and Advances. 70: C712-C712
Park J, Lin YS, De Schutter JW, et al. (2012) Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Structural Biology. 12: 32
De Schutter JW, Shaw J, Lin YS, et al. (2012) Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls. Bioorganic & Medicinal Chemistry. 20: 5583-91
Lin YS, Park J, De Schutter JW, et al. (2012) Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. Journal of Medicinal Chemistry. 55: 3201-15
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