David H. Kwan

Affiliations: 
2015- Biology Concordia University (Canada), Montreal, Canada 
Area:
Synthetic Biology
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"David Kwan"
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Parents

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Peter F. Leadlay grad student 2005-2009 Cambridge
Stephen G. Withers post-doc 2009-2015 UBC
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Publications

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Tegl G, Hanson J, Chen HM, et al. (2018) Facile Formation of β-thioGlcNAc Linkages to Thiol-Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase. Angewandte Chemie (International Ed. in English)
Kwan DH, Jin Y, Jiang J, et al. (2016) Chemoenzymatic synthesis of 6-phospho-cyclophellitol as a novel probe of 6-phospho-β-glucosidases. Febs Letters
Volkers G, Worrall LJ, Kwan DH, et al. (2015) Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation. Nature Structural & Molecular Biology. 22: 627-35
Kwan DH, Ernst S, Kötzler MP, et al. (2015) Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes. Glycobiology. 25: 806-11
Kwan DH, Constantinescu I, Chapanian R, et al. (2015) Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution. Journal of the American Chemical Society. 137: 5695-705
Volkers G, Worrall LJ, Kwan DH, et al. (2015) Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation Nature Structural and Molecular Biology
Chapanian R, Kwan DH, Constantinescu I, et al. (2014) Enhancement of biological reactions on cell surfaces via macromolecular crowding. Nature Communications. 5: 4683
Kwan DH, Withers SG. (2014) Periplasmic de-acylase helps bacteria don their biofilm coat. Proceedings of the National Academy of Sciences of the United States of America. 111: 10904-5
Yu CC, Hill T, Kwan DH, et al. (2014) A plate-based high-throughput activity assay for polysialyltransferase from Neisseria meningitidis. Analytical Biochemistry. 444: 67-74
Yu CC, Huang LD, Kwan DH, et al. (2013) A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis. Chemical Communications (Cambridge, England). 49: 10166-8
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