Kalub J. Hahne
Affiliations: | 2012 | Chemistry | Purdue University, West Lafayette, IN, United States |
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Sign in to add mentorChristine A. Hrycyna | grad student | 2012 | Purdue | |
(Characterization of the hydrophobic binding site of isoprenylcysteine carboxyl methyltransferase.) |
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Bergman JA, Hahne K, Song J, et al. (2012) S-Farnesyl-Thiopropionic Acid (FTPA) Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase. Acs Medicinal Chemistry Letters. 3: 15-19 |
Hahne K, Vervacke JS, Shrestha L, et al. (2012) Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes. Biochemical and Biophysical Research Communications. 423: 98-103 |
Majmudar JD, Hodges-Loaiza HB, Hahne K, et al. (2012) Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorganic & Medicinal Chemistry. 20: 283-95 |
Bergman JA, Hahne K, Hrycyna CA, et al. (2011) Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5616-9 |
Majmudar JD, Hahne K, Hrycyna CA, et al. (2011) Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 2616-20 |
Court H, Hahne K, Philips MR, et al. (2011) Biochemical and Biological Functions of Isoprenylcysteine Carboxyl Methyltransferase Enzymes. 30: 71-90 |
Griggs AM, Hahne K, Hrycyna CA. (2010) Functional oligomerization of the Saccharomyces cerevisiae isoprenylcysteine carboxyl methyltransferase, Ste14p. The Journal of Biological Chemistry. 285: 13380-7 |