Neil Bernard Madsen

Affiliations: 
Biochemistry University of Alberta, Edmonton, Alberta, Canada 
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"Neil Bernard Madsen"
Bio:

Dr. Neil B. Madsen, 89, of Victoria, BC, passed away peacefully March 22, 2017. He was a devoted husband, beloved father, scientist, Rotarian and outdoorsman. He was born February 8, 1928 in Grande Prairie, Alberta to Anders and Rose Madsen. He is predeceased by his loving wife of 46 years, Laura. Neil is survived by sisters Jean Stewart and Elizabeth Golosky; daughter Maureen, son Ian (Erica) and grandchildren Olivia, Talia and Julian Neil; stepsons Bill (Kitty), Jan (Ina), Preston (Lynda), and step-grandchildren Jennifer, Dimitri (Kristina), Kirstin, Morgan, Nikolas and Hamishe.

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Parents

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Jules Tuba grad student 1949-1952 University of Alberta (Cell Biology Tree)
 (Studies on alkaline phosphatase - M.Sc.)
Carl F. Cori grad student 1955 Washington University
 (The interactions of muscle phosphorylase with certain activators and inhibitors)
Hans Adolf Krebs post-doc 1956-1957 Oxford
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Publications

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Braun C, Lindhorst T, Madsen NB, et al. (1996) Identification of Asp 549 as the catalytic nucleophile of glycogen-debranching enzyme via trapping of the glycosyl-enzyme intermediate. Biochemistry. 35: 5458-63
Liu W, Madsen NB, Fan B, et al. (1995) Effects of oligosaccharide binding on glycogen debranching enzyme activity and conformation. Biochemistry. 34: 7056-61
Sprang SR, Madsen NB, Withers SG. (1992) Multiple phosphate positions in the catalytic site of glycogen phosphorylase: structure of the pyridoxal-5'-pyrophosphate coenzyme-substrate analog. Protein Science : a Publication of the Protein Society. 1: 1100-11
Liu W, Madsen NB, Braun C, et al. (1991) Reassessment of the catalytic mechanism of glycogen debranching enzyme. Biochemistry. 30: 1419-24
Sprang SR, Withers SG, Goldsmith EJ, et al. (1991) Structural basis for the activation of glycogen phosphorylase b by adenosine monophosphate. Science (New York, N.Y.). 254: 1367-71
Kornberg HL, Madsen NB. (1989) Synthesis of C4-dicarboxylic acids from acetate by a "glyoxylate bypass" of the tricarboxylic acid cycle. 1957. Biochimica Et Biophysica Acta. 1000: 275-7
Sprang SR, Acharya KR, Goldsmith EJ, et al. (1988) Structural changes in glycogen phosphorylase induced by phosphorylation. Nature. 336: 215-21
Scraba DG, Bradley RD, Fitzgerald PM, et al. (1988) Electron microscopy of glycogen degrading enzymes. Febs Letters. 240: 133-8
Takrama J, Madsen NB. (1988) Binding of glycogen, oligosaccharides, and glucose to glycogen debranching enzyme. Biochemistry. 27: 3308-14
Monanu MO, Madsen NB. (1987) Distinction between substrate- and enzyme-directed effects of modifiers of rabbit liver phosphorylase a phosphatases. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 65: 293-301
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