Neil Bernard Madsen

Affiliations: 
Biochemistry University of Alberta, Edmonton, Alberta, Canada 
Google:
"Neil Bernard Madsen"
Bio:

Dr. Neil B. Madsen, 89, of Victoria, BC, passed away peacefully March 22, 2017. He was a devoted husband, beloved father, scientist, Rotarian and outdoorsman. He was born February 8, 1928 in Grande Prairie, Alberta to Anders and Rose Madsen. He is predeceased by his loving wife of 46 years, Laura. Neil is survived by sisters Jean Stewart and Elizabeth Golosky; daughter Maureen, son Ian (Erica) and grandchildren Olivia, Talia and Julian Neil; stepsons Bill (Kitty), Jan (Ina), Preston (Lynda), and step-grandchildren Jennifer, Dimitri (Kristina), Kirstin, Morgan, Nikolas and Hamishe.

Neil distinguished himself in the field of biochemistry at the University of Alberta. He was a great scholar of world-class stature. His legacy in science is well entrenched in the historical record. After receiving the Gold Medal for academic excellence in his class in Agriculture at the U of A, he began Masters studies in 1950. He received his Ph.D. at Washington University in 1955, under Nobel Prize co-winners Carl and Gerty Cori. He subsequently did postdoctoral studies in the laboratory of another Nobel Prize winner, Hans Krebs, at Oxford. His life work was glycogen phosphorylase. He and x-ray crystallographer Robert Fletterick made the discovery of the detailed, complicated structure of that enzyme, crucial to human and animal metabolism. Later on, Neil did related work on glycogen-debranching enzyme. He collaborated with other researchers around the world, and had many Canadian and foreign doctoral and graduate student, and post-doctoral fellows benefit from guidance in his own lab in Edmonton. He was also president of the Canadian Society of Biological Sciences, a Fellow of the Royal Society of Canada, and a recipient of the Order of Canada and the Queen's Silver Jubilee Medal. He retired in 1993.

After 31 years he and Laura retired to the city of Victoria, BC. Neil was afforded the time to pursue the hobbies he enjoyed most: his gardening, roses in particular, boating and fishing. Neil was an active member of the Oak Bay Rotary Club. Always the smartest man in the room, his generous soul made an impact on those who knew him. A loving father who will be missed forever.
(Show less)

Mean distance: 8.73
 
SNBCP

Parents

Sign in to add mentor
Jules Tuba grad student 1949-1952 University of Alberta (Cell Biology Tree)
 (Studies on alkaline phosphatase - M.Sc.)
Carl F. Cori grad student 1955 Washington University
 (The interactions of muscle phosphorylase with certain activators and inhibitors)
Hans Adolf Krebs post-doc 1956-1957 Oxford
BETA: Related publications

Publications

You can help our author matching system! If you notice any publications incorrectly attributed to this author, please sign in and mark matches as correct or incorrect.

Braun C, Lindhorst T, Madsen NB, et al. (1996) Identification of Asp 549 as the catalytic nucleophile of glycogen-debranching enzyme via trapping of the glycosyl-enzyme intermediate. Biochemistry. 35: 5458-63
Liu W, Madsen NB, Fan B, et al. (1995) Effects of oligosaccharide binding on glycogen debranching enzyme activity and conformation. Biochemistry. 34: 7056-61
Sprang SR, Madsen NB, Withers SG. (1992) Multiple phosphate positions in the catalytic site of glycogen phosphorylase: structure of the pyridoxal-5'-pyrophosphate coenzyme-substrate analog. Protein Science : a Publication of the Protein Society. 1: 1100-11
Liu W, Madsen NB, Braun C, et al. (1991) Reassessment of the catalytic mechanism of glycogen debranching enzyme. Biochemistry. 30: 1419-24
Sprang SR, Withers SG, Goldsmith EJ, et al. (1991) Structural basis for the activation of glycogen phosphorylase b by adenosine monophosphate. Science (New York, N.Y.). 254: 1367-71
Kornberg HL, Madsen NB. (1989) Synthesis of C4-dicarboxylic acids from acetate by a "glyoxylate bypass" of the tricarboxylic acid cycle. 1957. Biochimica Et Biophysica Acta. 1000: 275-7
Sprang SR, Acharya KR, Goldsmith EJ, et al. (1988) Structural changes in glycogen phosphorylase induced by phosphorylation. Nature. 336: 215-21
Scraba DG, Bradley RD, Fitzgerald PM, et al. (1988) Electron microscopy of glycogen degrading enzymes. Febs Letters. 240: 133-8
Takrama J, Madsen NB. (1988) Binding of glycogen, oligosaccharides, and glucose to glycogen debranching enzyme. Biochemistry. 27: 3308-14
Monanu MO, Madsen NB. (1987) Distinction between substrate- and enzyme-directed effects of modifiers of rabbit liver phosphorylase a phosphatases. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 65: 293-301
See more...