Lance M. Hellman, Ph.D.

Affiliations: 
University of Kentucky, Lexington, KY 
Area:
Protein-nucleic acid interactions
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"Lance Hellman"
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Parents

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Michael G. Fried grad student 2011 University of Kentucky
 (The interaction of O6-alkylguanine-DNA alkyltransferase with human telomeric G-quadruplex DNAs containing O6-methylguanine adducts.)
Brian M. Baker post-doc 2013 Notre Dame
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Publications

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Singh NK, Alonso JA, Devlin JR, et al. (2022) A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry. Nature Communications. 13: 7189
Liu C, Liu H, Dasgupta M, et al. (2022) Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma. Scientific Reports. 12: 12068
Ma J, Ayres CM, Hellman LM, et al. (2021) Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor. The Journal of Biological Chemistry. 100686
Smith AR, Alonso JA, Ayres CM, et al. (2021) Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 118
Singh NK, Alonso JA, Harris DT, et al. (2020) An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes. Biochemistry
Ayres CM, Abualrous ET, Bailey A, et al. (2019) Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility. Frontiers in Immunology. 10: 966
Hellman LM, Foley KC, Singh NK, et al. (2018) Improving T Cell Receptor On-Target Specificity via Structure-Guided Design. Molecular Therapy : the Journal of the American Society of Gene Therapy
Riley TP, Hellman LM, Gee MH, et al. (2018) T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability. Nature Chemical Biology. 14: 934-942
Spear TT, Wang Y, Smith TW, et al. (2018) Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy
Moore T, Wagner CR, Scurti GM, et al. (2017) Correction to: Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells. Cancer Immunology, Immunotherapy : Cii
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