Jason C. Rech, Ph.D.

University of Pittsburgh, Pittsburgh, PA, United States 
Reaction Design, Total Synthesis, Mechanistic Analysis, Diversity Oriented Synthesis
"Jason Rech"
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Paul E. Floreancig grad student 2005 University of Pittsburgh
 (The development of an electron transfer initiated cyclization approach toward the total synthesis of mycalamide B. The synthesis of the N(7)-C(25) fragment of psymberin.)
Jonathan A. Ellman post-doc 2007 UC Berkeley College of Chemistry
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Rech JC, Bhattacharya A, Branstetter BJ, et al. (2016) The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists. Bioorganic & Medicinal Chemistry Letters
Swanson DM, Savall BM, Coe KJ, et al. (2016) The Identification of (R)-(2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a small molecule antagonist of the P2X7 receptor. Journal of Medicinal Chemistry
Rech JC, Bhattacharya A, Letavic MA, et al. (2016) The evolution of P2X7 antagonists with a focus on CNS indications. Bioorganic & Medicinal Chemistry Letters
Amhaoul H, Ali I, Mola M, et al. (2016) P2X7 receptor antagonism reduces severity of spontaneous seizures in a chronic model of temporal lobe epilepsy. Neuropharmacology
Chrovian CC, Soyode-Johnson A, Ao H, et al. (2016) Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3-a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain. Acs Chemical Neuroscience
Ameriks MK, Ao H, Carruthers NI, et al. (2015) Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists. Bioorganic & Medicinal Chemistry Letters
Rudolph DA, Alcazar J, Ameriks MK, et al. (2015) Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists. Bioorganic & Medicinal Chemistry Letters
Chrovian CC, Rech JC, Bhattacharya A, et al. (2014) P2X7 antagonists as potential therapeutic agents for the treatment of CNS disorders. Progress in Medicinal Chemistry. 53: 65-100
Letavic MA, Lord B, Bischoff F, et al. (2013) Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists. Acs Medicinal Chemistry Letters. 4: 419-22
Wan S, Wu F, Rech JC, et al. (2011) Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs. Journal of the American Chemical Society. 133: 16668-79
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