Brian B. Tuch, Ph.D.

Biological and Medical Informatics University of California, San Francisco, San Francisco, CA 
Molecular Biology of Transcription Circuit Evolution, Candida albicans pathogenesis
"Brian Tuch"
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Alexander D. Johnson grad student 2008 UCSF
 (Evolution of fungal transcription circuits.)
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Lowe E, Fan RA, Jiang J, et al. (2020) Preclinical evaluation of KZR-261, a novel small molecule inhibitor of Sec61. Journal of Clinical Oncology. 38: 3582-3582
Cocco E, Schram AM, Kulick A, et al. (2019) Resistance to TRK inhibition mediated by convergent MAPK pathway activation. Nature Medicine
Hong DS, Bauer TM, Lee JJ, et al. (2019) Larotrectinib in adult patients with solid tumours: a multicentre, open-label, phase I dose-escalation study. Annals of Oncology : Official Journal of the European Society For Medical Oncology
Lowe E, Fan AR, Jiang J, et al. (2019) Blocking Protein Secretion with Novel Small Molecule Inhibitors of Sec61 Represents a Potential Treatment Strategy Against Hematologic Malignancies Blood. 134: 408-408
Laetsch TW, DuBois SG, Mascarenhas L, et al. (2018) Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study. The Lancet. Oncology
Sorrells TR, Booth LN, Tuch BB, et al. (2015) Intersecting transcription networks constrain gene regulatory evolution. Nature. 523: 361-5
Enroth S, Andersson R, Bysani M, et al. (2014) Nucleosome regulatory dynamics in response to TGFβ. Nucleic Acids Research. 42: 6921-34
Nobile CJ, Fox EP, Nett JE, et al. (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell. 148: 126-38
Nobile CJ, Fox EP, Nett JE, et al. (2012) The transcriptional network controlling biofilm development in Candida albicans F1000research. 3
Chen C, Pande K, French SD, et al. (2011) An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. Cell Host & Microbe. 10: 118-35
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