William A. Freed-Pastor, Ph.D.

Biological Sciences Columbia University, New York, NY 
p53 tumour suppressor protein
"William Freed-Pastor"
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Carol L. Prives grad student 2012 Columbia
 (Gain-of-Function Effects of Mutant p53 Explored Using a Three-Dimensional Culture Model of Breast Cancer.)
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Moon SH, Huang CH, Houlihan SL, et al. (2018) p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell
Rastogi C, Rube HT, Kribelbauer JF, et al. (2018) Accurate and sensitive quantification of protein-DNA binding affinity. Proceedings of the National Academy of Sciences of the United States of America
Kribelbauer JF, Laptenko O, Chen S, et al. (2017) Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes. Cell Reports. 19: 2383-2395
Pfister NT, Fomin V, Regunath K, et al. (2015) Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes & Development. 29: 1298-315
Laptenko O, Shiff I, Freed-Pastor W, et al. (2015) The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain. Molecular Cell. 57: 1034-46
Freed-Pastor WA, Prives C. (2012) Mutant p53: one name, many proteins. Genes & Development. 26: 1268-86
Freed-Pastor WA, Mizuno H, Zhao X, et al. (2012) Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell. 148: 244-58
Freed-Pastor WA, Prives C. (2011) Dissimilar DNA binding by p53 in normal and tumor-derived cells. Cell Cycle (Georgetown, Tex.). 10: 4207
Kass EM, Ahn J, Tanaka T, et al. (2007) Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. The Journal of Biological Chemistry. 282: 30311-21
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