Scott L. Crick, Ph.D.

Affiliations: 
Biomedical Engineering Washington University, Saint Louis, St. Louis, MO 
Area:
protein folding, protein structure/function relationships, protein-protein interactions and the mechanisms of enzymatic reactions
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"Scott Crick"
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Carl Frieden grad student 2011 Washington University
 (Inferring Aggregation Mechanisms of Molecules Involved in Neurodegeneration through Quantitative Studies of Phase Behavior.)
Rohit V. Pappu grad student 2005-2011 Washington University (BME Tree)
 (Inferring Aggregation Mechanisms of Molecules Involved in Neurodegeneration through Quantitative Studies of Phase Behavior.)
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Publications

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Posey AE, Ruff KM, Harmon TS, et al. (2018) Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers. The Journal of Biological Chemistry
Crick SL, Ruff KM, Garai K, et al. (2013) Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation. Proceedings of the National Academy of Sciences of the United States of America. 110: 20075-80
Crick SL, Ruff KM, Garai K, et al. (2013) Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation Proceedings of the National Academy of Sciences of the United States of America. 110: 20075-20080
Shu Q, Crick SL, Pinkner JS, et al. (2012) The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism. Proceedings of the National Academy of Sciences of the United States of America. 109: 6502-7
Das RK, Crick SL, Pappu RV. (2012) N-terminal segments modulate the α-helical propensities of the intrinsically disordered basic regions of bZIP proteins. Journal of Molecular Biology. 416: 287-99
Crick SL, Mao AH, Pappu RV. (2012) Inferring Aggregation Mechanisms of Polyglutamine Through Quantitative Studies of Phase Behavior Biophysical Journal. 102: 11a
Crick SL, Pappu RV. (2012) Thermodynamic and Kinetic Models for Aggregation of Intrinsically Disordered Proteins Protein and Peptide Folding, Misfolding, and Non-Folding. 413-440
Das RK, Crick SL, Pappu RV. (2011) Intrinsic Helicity of Disordered Basic Regions of Bzip Transcription Factors: Implications For Mechanisms of DNA Binding Biophysical Journal. 100: 63a
Lyle NJ, Crick SL, Pappu RV. (2011) Alterations to the Conformational Ensemble and Intermolecular Associations of Polyglutamine Due to Charged Side Chains at the N- and C-Termini Biophysical Journal. 100: 63a
Das RK, Crick SL, Pappu RV. (2011) Intrinsic Disorder in the Basic Regions of bZIP Transcription Factors: What it Means to Be Disordered and Why it Might Matter! Biophysical Journal. 100: 519a
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