Shoshana Posy, Ph.D.

Affiliations: 
Columbia University, New York, NY 
Area:
computational biophysics and bioinformatics
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"Shoshana Posy"
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Barry H. Honig grad student 2008 Columbia
 (Sequence and structural determinants of strand swapping and binding affinity in cadherin domains.)
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Publications

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Chaudhry C, Davis J, Zhang Y, et al. (2015) Building HTRF assays for characterization of bivalent inhibitors of an Inhibitor of Apoptosis Protein target. Analytical Biochemistry
Vendome J, Posy S, Jin X, et al. (2011) Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nature Structural & Molecular Biology. 18: 693-700
Ciatto C, Bahna F, Zampieri N, et al. (2010) T-cadherin structures reveal a novel adhesive binding mechanism. Nature Structural & Molecular Biology. 17: 339-47
Katsamba P, Carroll K, Ahlsen G, et al. (2009) Linking molecular affinity and cellular specificity in cadherin-mediated adhesion. Proceedings of the National Academy of Sciences of the United States of America. 106: 11594-9
Posy S, Shapiro L, Honig B. (2008) Sequence and structural determinants of strand swapping in cadherin domains: do all cadherins bind through the same adhesive interface? Journal of Molecular Biology. 378: 954-68
Koehnke J, Jin X, Budreck EC, et al. (2008) Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2. Proceedings of the National Academy of Sciences of the United States of America. 105: 1873-8
Ortiz CO, Etchberger JF, Posy SL, et al. (2006) Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Genetics. 173: 131-49
Chen CP, Posy S, Ben-Shaul A, et al. (2005) Specificity of cell-cell adhesion by classical cadherins: Critical role for low-affinity dimerization through beta-strand swapping. Proceedings of the National Academy of Sciences of the United States of America. 102: 8531-6
Tang CL, Xie L, Koh IY, et al. (2003) On the role of structural information in remote homology detection and sequence alignment: new methods using hybrid sequence profiles. Journal of Molecular Biology. 334: 1043-62
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