Shoshana Posy, Ph.D.

Affiliations: 
Columbia University, New York, NY 
Area:
computational biophysics and bioinformatics
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"Shoshana Posy"
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Barry H. Honig grad student 2008 Columbia
 (Sequence and structural determinants of strand swapping and binding affinity in cadherin domains.)
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Publications

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Vendome J, Posy S, Jin X, et al. (2011) Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nature Structural & Molecular Biology. 18: 693-700
Ciatto C, Bahna F, Zampieri N, et al. (2010) T-cadherin structures reveal a novel adhesive binding mechanism. Nature Structural & Molecular Biology. 17: 339-47
Katsamba P, Carroll K, Ahlsen G, et al. (2009) Linking molecular affinity and cellular specificity in cadherin-mediated adhesion. Proceedings of the National Academy of Sciences of the United States of America. 106: 11594-9
Posy S, Shapiro L, Honig B. (2008) Sequence and structural determinants of strand swapping in cadherin domains: do all cadherins bind through the same adhesive interface? Journal of Molecular Biology. 378: 954-68
Koehnke J, Jin X, Budreck EC, et al. (2008) Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2. Proceedings of the National Academy of Sciences of the United States of America. 105: 1873-8
Ortiz CO, Etchberger JF, Posy SL, et al. (2006) Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Genetics. 173: 131-49
Chen CP, Posy S, Ben-Shaul A, et al. (2005) Specificity of cell-cell adhesion by classical cadherins: Critical role for low-affinity dimerization through beta-strand swapping. Proceedings of the National Academy of Sciences of the United States of America. 102: 8531-6
Tang CL, Xie L, Koh IY, et al. (2003) On the role of structural information in remote homology detection and sequence alignment: new methods using hybrid sequence profiles. Journal of Molecular Biology. 334: 1043-62
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