Aaron T. Jacobs, Ph.D.

University of California, Los Angeles, Los Angeles, CA
regulation and modulation of nitric oxide (NO) production and cytotoxicity in macrophages, vascular cells, and tumor cells
"Aaron Jacobs"
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Louis J. Ignarro grad student 2003 UCLA
 (Regulation of the LPS-induced cytotoxic response in murine macrophages: Roles of nitric oxide and autocrine IFN-beta;)
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Siraj MA, Jacobs AT, Tan GT. (2022) Altersolanol B, a fungal tetrahydroanthraquinone, inhibits the proliferation of estrogen receptor-expressing (ER+) human breast adenocarcinoma by modulating PI3K/AKT, p38/ERK MAPK and associated signaling pathways. Chemico-Biological Interactions. 359: 109916
Connelly L, Yadav N, Barcikowski A, et al. (2017) Abstract P4-03-13: Obesity and breast cancer: The adipocyte-macrophage interaction as a mediator of metastasis Cancer Research. 77
Pinner KD, Wales CT, Gristock RA, et al. (2016) Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes. Pharmaceutical Biology. 1-10
Wales CT, Taylor FR, Higa AT, et al. (2015) ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells. Anti-Cancer Drugs. 26: 657-66
Wales CT, Gristock R, So N, et al. (2015) Abstract 1246: c-Myc is critical for apoptosis in 4-hyroxynonenal-treated colorectal cancer cells Cancer Research. 75: 1246-1246
Samarasinghe B, Wales CT, Taylor FR, et al. (2014) Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochemical Pharmacology. 87: 445-55
Wales CTK, Jacobs AT. (2014) Abstract 681: Heat shock-mediated suppression of ODC protein expression in colorectal cancer cells Cancer Research. 74: 681-681
Cusick JK, Sumida C, Checketts M, et al. (2014) Abstract 2264: HIC (MDFIC) is a protein that interacts and colocalizes with the RELT family of TNFRs Cancer Research. 74: 2264-2264
Yadav NVS, Jacobs AT, Connelly L. (2014) Abstract 1096: Investigating the role of the adipocyte-macrophage interaction in breast cancer metastasis Cancer Research. 74: 1096-1096
Wales CTK, Jacobs AT. (2013) Abstract 763: Hyperthermia promotes c-myc turnover and reduces ODC expression in colorectal cancer cells. Cancer Research. 73: 763-763
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