Aaron T. Jacobs, Ph.D.

Institution:
University of California, Los Angeles, Los Angeles, CA
Area:
regulation and modulation of nitric oxide (NO) production and cytotoxicity in macrophages, vascular cells, and tumor cells
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"Aaron Jacobs"
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Parents

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Louis J. Ignarro grad student 2003 UCLA
 (Regulation of the LPS-induced cytotoxic response in murine macrophages: Roles of nitric oxide and autocrine IFN-beta;)
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Publications

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Siraj MA, Jacobs AT, Tan GT. (2022) Altersolanol B, a fungal tetrahydroanthraquinone, inhibits the proliferation of estrogen receptor-expressing (ER+) human breast adenocarcinoma by modulating PI3K/AKT, p38/ERK MAPK and associated signaling pathways. Chemico-Biological Interactions. 359: 109916
Connelly L, Yadav N, Barcikowski A, et al. (2017) Abstract P4-03-13: Obesity and breast cancer: The adipocyte-macrophage interaction as a mediator of metastasis Cancer Research. 77
Pinner KD, Wales CT, Gristock RA, et al. (2016) Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes. Pharmaceutical Biology. 1-10
Wales CT, Taylor FR, Higa AT, et al. (2015) ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells. Anti-Cancer Drugs. 26: 657-66
Wales CT, Gristock R, So N, et al. (2015) Abstract 1246: c-Myc is critical for apoptosis in 4-hyroxynonenal-treated colorectal cancer cells Cancer Research. 75: 1246-1246
Samarasinghe B, Wales CT, Taylor FR, et al. (2014) Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochemical Pharmacology. 87: 445-55
Wales CTK, Jacobs AT. (2014) Abstract 681: Heat shock-mediated suppression of ODC protein expression in colorectal cancer cells Cancer Research. 74: 681-681
Cusick JK, Sumida C, Checketts M, et al. (2014) Abstract 2264: HIC (MDFIC) is a protein that interacts and colocalizes with the RELT family of TNFRs Cancer Research. 74: 2264-2264
Yadav NVS, Jacobs AT, Connelly L. (2014) Abstract 1096: Investigating the role of the adipocyte-macrophage interaction in breast cancer metastasis Cancer Research. 74: 1096-1096
Wales CTK, Jacobs AT. (2013) Abstract 763: Hyperthermia promotes c-myc turnover and reduces ODC expression in colorectal cancer cells. Cancer Research. 73: 763-763
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