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Alan Finkelstein, Ph.D.

Physiology & Biophysics, and Neuroscience Albert Einstein College of Medicine, New York, New York, United States 
Ion-Conducting Channels Incorporated into Planar Lipid Bilayer Membranes
"Alan Finkelstein"

Alan Finkelstein received his Ph.D. from The Rockefeller University and was subsequently invited to join the faculty of the Albert Einstein College of Medicine, where he has remained. He has a long-term interest in transport across membranes, and a more recent fascination with protein translocation. His research has included the permeability properties of planar lipid bilayer membranes, the fusion of lipid vesicles with these membranes, and the properties of channels reconstituted in them. These properties include: water, nonelectrolyte and ion flow through the channels, single-file transport, and voltage gating. In work on diphtheria and the channel-forming colicins, his laboratory has discovered and studied protein translocation associated with their voltage gating. Work on the anthrax toxin has been concerned with how the channel-forming component of the toxin acts to unfold its other protein components and serves as conduit for their translocation.

Mean distance: 13.15 (cluster 32)
Cross-listing: Neurotree


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Myles H. Akabas grad student Albert Einstein (Neurotree)
Robert O. Blaustein grad student Albert Einstein (Neurotree)
Eric J. Heyer grad student Albert Einstein (Neurotree)
David Hoch grad student Albert Einstein (Neurotree)
Ronald W. Holz grad student Albert Einstein (Neurotree)
Paul Hyunh grad student Albert Einstein (Neurotree)
Bruce L. Kagan grad student Albert Einstein
Joseph A. Mindell grad student Albert Einstein (Neurotree)
Robert U. Muller grad student Albert Einstein (Neurotree)
Eli Orbach grad student Albert Einstein (Neurotree)
Lynn Raymond grad student Albert Einstein (Neurotree)
Myriam Romero grad student Albert Einstein (Neurotree)
Paul A. Rosenberg grad student Albert Einstein (Neurotree)
Lisa Senzel grad student Albert Einstein (Neurotree)
Joshua Zimmerberg grad student Albert Einstein
Shilla Nassi grad student 2002 Yeshiva University (Neurotree)
Michael  B. Gordon grad student 2003 Yeshiva University (Neurotree)
Daniel Basilio grad student 2005-2011 Yeshiva University
Eshwar B. Udho grad student 2012 Yeshiva University
Albert H. Cass post-doc Albert Einstein (Neurotree)
Fredric S. Cohen post-doc Albert Einstein
Marco Colombini post-doc Albert Einstein
Paul K. Kienker post-doc Albert Einstein
Alain Marty post-doc Albert Einstein (Neurotree)
Stanley Misler post-doc Albert Einstein (Neurotree)
Walter D. Niles post-doc Albert Einstein (Neurotree)
Stephen L. Slatin post-doc Albert Einstein (Neurotree)
Wamberto A. Varanda post-doc Albert Einstein (Neurotree)
Zhengyan Wu post-doc Albert Einstein (Neurotree)
David Zopf post-doc Albert Einstein (Neurotree)
Barbara E. Ehrlich post-doc 1980-1986 Albert Einstein (Neurotree)
Karen S. Jakes research scientist Albert Einstein
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Kienker PK, Wu Z, Finkelstein A. (2015) Topography of the TH5 Segment in the Diphtheria Toxin T-Domain Channel. The Journal of Membrane Biology
Schiffmiller A, Anderson D, Finkelstein A. (2015) Ion selectivity of the anthrax toxin channel and its effect on protein translocation. The Journal of General Physiology. 146: 183-92
Thomson R, Finkelstein A. (2015) Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis. Proceedings of the National Academy of Sciences of the United States of America. 112: 2894-9
Kienker PK, Wu Z, Finkelstein A. (2015) Mapping the membrane topography of the TH6-TH7 segment of the diphtheria toxin T-domain channel. The Journal of General Physiology. 145: 107-25
Schiffmiller A, Finkelstein A. (2015) Ion conductance of the stem of the anthrax toxin channel during lethal factor translocation. Journal of Molecular Biology. 427: 1211-23
Vargas-Uribe M, Rodnin MV, Kienker P, et al. (2014) Crucial Role of H322 in the Folding of Diphtheria Toxin T-Domain into the Open-Channel State Biophysical Journal. 106: 717a
Vargas-Uribe M, Rodnin MV, Kienker P, et al. (2013) Crucial role of H322 in folding of the diphtheria toxin T-domain into the open-channel state. Biochemistry. 52: 3457-63
Kienker P, Wu Z, Finkelstein A. (2013) Mapping the Membrane Topography of Segments TH6-TH7 and TH8-TH9 in the Diphtheria Toxin T-Domain Channel Biophysical Journal. 104: 240a
Udho E, Jakes KS, Finkelstein A. (2012) TonB-dependent transporter FhuA in planar lipid bilayers: partial exit of its plug from the barrel. Biochemistry. 51: 6753-9
Kienker P, Wu Z, Finkelstein A. (2012) Evidence for a TH6-TH7 Transmembrane Hairpin in the Diphtheria Toxin T-Domain Open Channel State Biophysical Journal. 102: 657a
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