Lauren E. Brown, Ph.D.

Affiliations: 
University of California, Santa Cruz, Santa Cruz, CA, United States 
Area:
Synthetic organic chemistry; heterocyclic chemistry, bio-organic chemistry
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"Lauren Brown"
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Parents

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Nicos A. Petasis research assistant 2001-2003 USC
Joseph P. Konopelski grad student 2009 UC Santa Cruz
 (Synthetic studies toward welwistatin, psymberin and a protective pharmaceutical.)
Scott E. Schaus post-doc 2009-2012 Boston University
John A. Porco, Jr. research scientist 2012-2014 Boston University
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Publications

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Chatterjee S, Yabaji SM, Rukhlenko OS, et al. (2021) Channeling macrophage polarization by rocaglates increases macrophage resistance to . Iscience. 24: 102845
Brown LE, França UL, McManus ML. (2021) Socioeconomic Disadvantage and Distance to Pediatric Critical Care. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Viarengo-Baker LA, Brown LE, Rzepiela AA, et al. (2021) Defining and navigating macrocycle chemical space. Chemical Science. 12: 4309-4328
Marcyk PT, LeBlanc EV, Kuntz DA, et al. (2021) Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. Journal of Medicinal Chemistry
Bock MJ, Brown LE, Wenning RJ, et al. (2020) Sources of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Other Dioxins in Lower Passaic River, NJ, Sediments. Environmental Toxicology and Chemistry
Iyer KR, Camara K, Daniel-Ivad M, et al. (2020) An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature Communications. 11: 6429
Levi-Galibov O, Lavon H, Wassermann-Dozorets R, et al. (2020) Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. Nature Communications. 11: 6245
Iyer KR, Whitesell L, Porco JA, et al. (2020) Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris. Mbio. 11
Chu J, Zhang W, Cencic R, et al. (2020) Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F. Cell Reports
Lehman SL, Wechsler T, Schwartz KR, et al. (2020) Abstract 6507: Inhibition of the translation initiation factor eIF4A1 enhances tumor cell radiosensitivity Cancer Research. 80: 6507-6507
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