Christine M. Dunham, Ph.D.

Affiliations: 
Emory University, Atlanta, GA 
Area:
RNA structure, catalysis and the origin of life
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Parents

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William Gregory Scott grad student 2003 UC Santa Cruz
 (Structural and mechanistic studies of an RNA enzyme.)
Venkatraman Ramakrishnan post-doc 2004-2008 MRC-LMB

Children

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Crystal Fagan grad student Emory
Eric D. Hoffer grad student Emory
Ha An Nguyen grad student Emory
Ian J. Pavelich grad student Emory
Marc Schureck grad student Emory
Pooja Srinivas grad student Emory
Jack A. Dunkle post-doc Emory
Samuel Hong post-doc Emory
Tatsuya Maehigashi post-doc Emory (Neurotree)
Ajchareeya Ruangprasert post-doc Emory
S. Sunita post-doc Emory
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Publications

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Srinivas P, Keiler KC, Dunham CM. (2022) Druggable differences: Targeting mechanistic differences between trans-translation and translation for selective antibiotic action. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2200046
Laughlin ZT, Nandi S, Dey D, et al. (2022) 50S subunit recognition and modification by the ribosomal RNA methyltransferase TlyA. Proceedings of the National Academy of Sciences of the United States of America. 119: e2120352119
Dai W, Darst SA, Dunham CM, et al. (2021) Seeing gene expression in cells: the future of structural biology. Faculty Reviews. 10: 79
Srinivas P, Steiner RE, Pavelich IJ, et al. (2021) Oxidation alters the architecture of the phenylalanyl-tRNA synthetase editing domain to confer hyperaccuracy. Nucleic Acids Research
Aron ZD, Mehrani A, Hoffer ED, et al. (2021) trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nature Communications. 12: 1799
Hoffer E, Hong S, Sunita S, et al. (2020) Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing. Elife. 9
Nguyen HA, Sunita S, Dunham CM. (2020) Disruption of evolutionarily correlated tRNA elements impairs accurate decoding. Proceedings of the National Academy of Sciences of the United States of America
Dey D, Hoffer ED, Francis D, et al. (2020) Aminoglycoside conformation and ring substituents dictate evasion from bacterial resistance mechanisms The Faseb Journal. 34: 1-1
Dunham C, Hoffer ED, An Nguyen H, et al. (2020) Role of RNA Modifications in tRNA Structural Stability and Accurate Protein Synthesis Biophysical Journal. 118: 181a-182a
Nosrati M, Dey D, Mehrani A, et al. (2019) Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition. The Journal of Biological Chemistry
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