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Jason Key, Ph.D.

Affiliations: 
University of Chicago, Chicago, IL 
Area:
dynamic X-ray diffraction studies of macromolecules; natural and engineered photoreceptors
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"Jason Key"
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Parents

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Keith Moffat grad student 2004 Chicago
 (X-ray crystallographic studies of bacterial oxygen sensor proteins.)
Kevin H. Gardner post-doc 2007-2011 UT Southwestern

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Publications

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Corrêa F, Key J, Kuhlman B, et al. (2016) Computational Repacking of HIF-2α Cavity Replaces Water-Based Stabilized Core. Structure (London, England : 1993)
Meyer PA, Socias S, Key J, et al. (2016) Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882
Scheuermann TH, Li Q, Ma HW, et al. (2013) Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nature Chemical Biology. 9: 271-6
Rogers JL, Bayeh L, Scheuermann TH, et al. (2013) Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. Journal of Medicinal Chemistry. 56: 1739-47
Guo Y, Partch CL, Key J, et al. (2013) Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. Acs Chemical Biology. 8: 626-35
Key J, Scheuermann TH, Anderson PC, et al. (2009) Principles of ligand binding within a completely buried cavity in HIF2α PAS-B Journal of the American Chemical Society. 131: 17647-17654
van Wilderen LJ, Key JM, Van Stokkum IH, et al. (2009) Dynamics of carbon monoxide photodissociation in Bradyrhizobium japonicum FixL probed by picosecond midinfrared spectroscopy. The Journal of Physical Chemistry. B. 113: 3292-7
Key J, Srajer V, Pahl R, et al. (2007) Time-resolved crystallographic studies of the heme domain of the oxygen sensor FixL: structural dynamics of ligand rebinding and their relation to signal transduction. Biochemistry. 46: 4706-15
Key J, Hefti M, Purcell EB, et al. (2007) Structure of the redox sensor domain of Azotobacter vinelandii NifL at atomic resolution: signaling, dimerization, and mechanism. Biochemistry. 46: 3614-23
Key J, Moffat K. (2005) Crystal structures of deoxy and CO-bound bjFixLH reveal details of ligand recognition and signaling. Biochemistry. 44: 4627-35
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