Catherine M. Eakin, Ph.D.

Yale University, New Haven, CT 
Protein Folding and Dynamics, Structural Biology
"Catherine Eakin"
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Andrew D. Miranker grad student 2005 Yale
 (Origins of transition metal mediated amyloidosis of Beta2-microglobulin.)
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Prentice KM, Wallace A, Eakin CM. (2015) Inline protein A mass spectrometry for characterization of monoclonal antibodies. Analytical Chemistry. 87: 2023-8
Eakin CM, Miller A, Kerr J, et al. (2014) Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies. Frontiers in Pharmacology. 5: 87
Prentice KM, Gillespie R, Lewis N, et al. (2013) Hydroxocobalamin association during cell culture results in pink therapeutic proteins. Mabs. 5: 974-81
Valliere-Douglass JF, Eakin CM, Wallace A, et al. (2010) Glutamine-linked and non-consensus asparagine-linked oligosaccharides present in human recombinant antibodies define novel protein glycosylation motifs. The Journal of Biological Chemistry. 285: 16012-22
Levin I, Eakin C, Blanc MP, et al. (2010) Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligase. Proceedings of the National Academy of Sciences of the United States of America. 107: 2848-53
Calabrese MF, Eakin CM, Wang JM, et al. (2008) A regulatable switch mediates self-association in an immunoglobulin fold. Nature Structural & Molecular Biology. 15: 965-71
Heikaus CC, Stout JR, Sekharan MR, et al. (2008) Solution structure of the cGMP binding GAF domain from phosphodiesterase 5: insights into nucleotide specificity, dimerization, and cGMP-dependent conformational change. The Journal of Biological Chemistry. 283: 22749-59
Eakin CM, Maccoss MJ, Finney GL, et al. (2007) Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligase. Proceedings of the National Academy of Sciences of the United States of America. 104: 5794-9
Eakin CM, Berman AJ, Miranker AD. (2006) A native to amyloidogenic transition regulated by a backbone trigger. Nature Structural & Molecular Biology. 13: 202-8
Eakin CM, Miranker AD. (2005) From chance to frequent encounters: origins of beta2-microglobulin fibrillogenesis. Biochimica Et Biophysica Acta. 1753: 92-9
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