Matthew F. Calabrese, Ph.D.

Yale University, New Haven, CT 
Protein Folding and Dynamics, Structural Biology
"Matthew Calabrese"
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Andrew D. Miranker grad student 2009 Yale
 (Copper ion-dependent amyloid formation by Beta 2-microglobulin.)
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Cameron KO, Kung DW, Kalgutkar AS, et al. (2016) Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. Journal of Medicinal Chemistry
Calabrese MF, Rajamohan F, Harris MS, et al. (2014) Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms. Structure (London, England : 1993). 22: 1161-72
Li G, Ci W, Karmakar S, et al. (2014) SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell. 25: 455-68
Landgraf RR, Goswami D, Rajamohan F, et al. (2013) Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry. Structure (London, England : 1993). 21: 1942-53
Werner A, Disanza A, Reifenberger N, et al. (2013) SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression. Nature Cell Biology. 15: 179-88
Calabrese MF, Scott DC, Duda DM, et al. (2011) A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases. Nature Structural & Molecular Biology. 18: 947-9
Duda DM, Scott DC, Calabrese MF, et al. (2011) Structural regulation of cullin-RING ubiquitin ligase complexes. Current Opinion in Structural Biology. 21: 257-64
Wolfe LS, Calabrese MF, Nath A, et al. (2010) Protein-induced photophysical changes to the amyloid indicator dye thioflavin T. Proceedings of the National Academy of Sciences of the United States of America. 107: 16863-8
Zhuang M, Calabrese MF, Liu J, et al. (2009) Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Molecular Cell. 36: 39-50
Calabrese MF, Miranker AD. (2009) Metal binding sheds light on mechanisms of amyloid assembly. Prion. 3: 1-4
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