Matthew F. Calabrese, Ph.D.

Yale University, New Haven, CT 
Protein Folding and Dynamics, Structural Biology
"Matthew Calabrese"
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Andrew D. Miranker grad student 2009 Yale
 (Copper ion-dependent amyloid formation by Beta 2-microglobulin.)
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Ryder T, Calabrese MF, Walker GS, et al. (2018) Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-activated Protein Kinase (AMPK). Journal of Medicinal Chemistry
Zorba A, Nguyen C, Xu Y, et al. (2018) Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proceedings of the National Academy of Sciences of the United States of America
Kurumbail RG, West GM, Dharmarajan V, et al. (2018) Biophysical Interactions of Direct AMPK Activators. Methods in Molecular Biology (Clifton, N.J.). 1732: 29-55
Salatto CT, Miller RA, Cameron KO, et al. (2017) Selective Activation of AMPK b1-containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. The Journal of Pharmacology and Experimental Therapeutics
Kurumbail RG, Calabrese MF. (2016) Structure and Regulation of AMPK. Exs. 107: 3-22
Cameron KO, Kung DW, Kalgutkar AS, et al. (2016) Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. Journal of Medicinal Chemistry
Rajamohan F, Reyes AR, Frisbie RK, et al. (2015) Probing the Enzyme Kinetics, Allosteric Modulation and Activation of Alpha-1 and Alpha-2 Subunit Containing AMP-activated Protein Kinase (AMPK) Heterotrimeric Complexes by Pharmacological and Physiological Activators. The Biochemical Journal
Calabrese MF, Rajamohan F, Harris MS, et al. (2014) Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms. Structure (London, England : 1993). 22: 1161-72
Landgraf RR, Goswami D, Rajamohan F, et al. (2013) Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry. Structure (London, England : 1993). 21: 1942-53
Duda DM, Scott DC, Calabrese MF, et al. (2011) Structural regulation of cullin-RING ubiquitin ligase complexes. Current Opinion in Structural Biology. 21: 257-64
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