James A. Hebda, Ph.D.

Affiliations: 
Yale University, New Haven, CT 
Area:
Protein Folding and Dynamics, Structural Biology
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"James Hebda"
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Andrew D. Miranker grad student 2011 Yale
 (Elucidating the Mechanism of Amyloid Assembly in Islet Amyloid Polypeptide Through Small Molecule Interference.)
Patricia O'Hara post-doc Amherst College
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Publications

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Kumar S, Schlamadinger DE, Brown MA, et al. (2015) Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics. Chemistry & Biology. 22: 369-78
Hebda JA, Magzoub M, Miranker AD. (2014) Small molecule screening in context: lipid-catalyzed amyloid formation. Protein Science : a Publication of the Protein Society. 23: 1341-8
Saraogi I, Hebda JA, Becerril J, et al. (2010) Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. Angewandte Chemie (International Ed. in English). 49: 736-9
Hebda JA, Saraogi I, Magzoub M, et al. (2009) A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chemistry & Biology. 16: 943-50
Hebda JA, Miranker AD. (2009) The interplay of catalysis and toxicity by amyloid intermediates on lipid bilayers: insights from type II diabetes. Annual Review of Biophysics. 38: 125-52
Koo BW, Hebda JA, Miranker AD. (2008) Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide. Protein Engineering, Design & Selection : Peds. 21: 147-54
Knight JD, Hebda JA, Miranker AD. (2006) Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide. Biochemistry. 45: 9496-508
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