James A. Hebda, Ph.D.
Affiliations: | Yale University, New Haven, CT |
Area:
Protein Folding and Dynamics, Structural BiologyGoogle:
"James Hebda"Mean distance: 8.99
Parents
Sign in to add mentorAndrew D. Miranker | grad student | 2011 | Yale | |
(Elucidating the Mechanism of Amyloid Assembly in Islet Amyloid Polypeptide Through Small Molecule Interference.) | ||||
Patricia O'Hara | post-doc | Amherst College |
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Publications
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Kumar S, Schlamadinger DE, Brown MA, et al. (2015) Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics. Chemistry & Biology. 22: 369-78 |
Hebda JA, Magzoub M, Miranker AD. (2014) Small molecule screening in context: lipid-catalyzed amyloid formation. Protein Science : a Publication of the Protein Society. 23: 1341-8 |
Cabrejo R, Hebda J, O'Hara PB. (2014) Clarifying the Intersection Between Alpha-Crystallin B Function and Oligomerization by Altering Aggregation Conditions Biophysical Journal. 106: 471a |
Schlamadinger DE, Kumar S, Magzoub M, et al. (2013) Inhibition and Mechanism of Islet Amyloid Polypeptide Toxicity Biophysical Journal. 104: 56a |
Cheng KW, Cabrejo RG, Pearlman AH, et al. (2013) Clarifying Alpha Crystallin Chaperone Function by using an Insulin B-Chain Aggregation Model Biophysical Journal. 104: 48a |
Hebda JA, Pearlman A, O'Hara PB. (2013) Characterizing the Role of Palindromic Strand Exchange in Alpha Crystallin Oligomerization Biophysical Journal. 104: 394a |
Santos J, Cabrejo R, O'Hara P, et al. (2012) Elucidating Molecular Constraints that Effect Alpha Crystallin Oligomerization, Stability, and Chaperone Function Biophysical Journal. 102: 60a |
Saraogi I, Hebda JA, Becerril J, et al. (2010) Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. Angewandte Chemie (International Ed. in English). 49: 736-9 |
Magzoub M, Hebda JA, Miranker A. (2010) Small Molecule Inhibitors of Islet Amyloid Polypeptide Fibrillogenesis and Cytotoxicity Biophysical Journal. 98: 255a |
Hebda JA, Saraogi I, Magzoub M, et al. (2009) A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chemistry & Biology. 16: 943-50 |