James A. Hebda, Ph.D.

Affiliations: 
Yale University, New Haven, CT 
Area:
Protein Folding and Dynamics, Structural Biology
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"James Hebda"
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Andrew D. Miranker grad student 2011 Yale
 (Elucidating the Mechanism of Amyloid Assembly in Islet Amyloid Polypeptide Through Small Molecule Interference.)
Patricia O'Hara post-doc Amherst College
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Publications

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Kumar S, Schlamadinger DE, Brown MA, et al. (2015) Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics. Chemistry & Biology. 22: 369-78
Hebda JA, Magzoub M, Miranker AD. (2014) Small molecule screening in context: lipid-catalyzed amyloid formation. Protein Science : a Publication of the Protein Society. 23: 1341-8
Cabrejo R, Hebda J, O'Hara PB. (2014) Clarifying the Intersection Between Alpha-Crystallin B Function and Oligomerization by Altering Aggregation Conditions Biophysical Journal. 106: 471a
Schlamadinger DE, Kumar S, Magzoub M, et al. (2013) Inhibition and Mechanism of Islet Amyloid Polypeptide Toxicity Biophysical Journal. 104: 56a
Cheng KW, Cabrejo RG, Pearlman AH, et al. (2013) Clarifying Alpha Crystallin Chaperone Function by using an Insulin B-Chain Aggregation Model Biophysical Journal. 104: 48a
Hebda JA, Pearlman A, O'Hara PB. (2013) Characterizing the Role of Palindromic Strand Exchange in Alpha Crystallin Oligomerization Biophysical Journal. 104: 394a
Santos J, Cabrejo R, O'Hara P, et al. (2012) Elucidating Molecular Constraints that Effect Alpha Crystallin Oligomerization, Stability, and Chaperone Function Biophysical Journal. 102: 60a
Saraogi I, Hebda JA, Becerril J, et al. (2010) Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. Angewandte Chemie (International Ed. in English). 49: 736-9
Magzoub M, Hebda JA, Miranker A. (2010) Small Molecule Inhibitors of Islet Amyloid Polypeptide Fibrillogenesis and Cytotoxicity Biophysical Journal. 98: 255a
Hebda JA, Saraogi I, Magzoub M, et al. (2009) A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chemistry & Biology. 16: 943-50
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