James R. Fuchs, Ph.D.
Affiliations: | Pennsylvania State University, State College, PA, United States | ||
| 2007- | Medicinal Chemistry and Pharmacognosy | Ohio State University, Columbus, Columbus, OH |
Area:
Natural products synthesisWebsite:
http://pharmacy.osu.edu/faculty-staff/users/fuchs42Google:
"James R. Fuchs"Bio:
http://www.scripps.edu/boger/Group%20Alumni%203.html
Mean distance: 8.46 | S | N | B | C | P |
Parents
Sign in to add mentor| Raymond L. Funk | grad student | 2005 | Penn State | |
| (New strategies for the synthesis of polycyclic natural products: Total syntheses of lennoxamine, aphanorphine, flustramine A, flustramine C, and perophoramidine.) | ||||
| Dale L. Boger | post-doc | 2005-2007 | Scripps Institute | |
Children
Sign in to add trainee| Jonathan Etter | grad student | Ohio State | |
| Pratiq Patel | grad student | Ohio State | |
| Daniel Adu Ampratwum | post-doc | 2016- | Ohio State |
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Publications
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| Dinh T, Tber Z, Rey JS, et al. (2024) The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir. Biorxiv : the Preprint Server For Biology |
| Bester SM, Adu-Ampratwum D, Annamalai AS, et al. (2022) Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio. e0180422 |
| Adu-Ampratwum D, Pan Y, Koneru PC, et al. (2022) Identification and Optimization of a Novel HIV-1 Integrase Inhibitor. Acs Omega. 7: 4482-4491 |
| Amrine CSM, Huntsman AC, Doyle MG, et al. (2021) Semisynthetic Derivatives of the Verticillin Class of Natural Products through Acylation of the C11 Hydroxy Group. Acs Medicinal Chemistry Letters. 12: 625-630 |
| Bester SM, Wei G, Zhao H, et al. (2020) Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science (New York, N.Y.). 370: 360-364 |
| Koneru PC, Francis AC, Deng N, et al. (2019) HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife. 8 |
| Wilson TA, Koneru PC, Rebensburg SV, et al. (2019) An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors. Acs Medicinal Chemistry Letters. 10: 215-220 |
| Young AN, Herrera D, Huntsman AC, et al. (2018) Phyllanthusmin derivatives induce apoptosis and reduce tumor burden in high grade serous ovarian cancer by late-stage autophagy inhibition. Molecular Cancer Therapeutics |
| Woodard JL, Huntsman AC, Patel PA, et al. (2018) Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones. Bioorganic & Medicinal Chemistry |
| Hoyte AC, Jamin AV, Koneru PC, et al. (2017) Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing. The Journal of Biological Chemistry. 292: 19814-19825 |