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James E. Rothman

1978-1988 Biochemistry Stanford University, Palo Alto, CA 
 1988-1991 Molecular Biology Princeton University, Princeton, NJ 
 1991-2004 Cellular Biochemistry and Biophysics Memorial Sloan-Kettering Cancer Center, Rockville Centre, NY, United States 
 2004-2008 Cellular Biophysics Columbia University, New York, NY 
 2008- Cell Biology Yale University, New Haven, CT 
Secretion, membrane fusion
"James E. Rothman"
Discovered most of the eukaryotic SNARE-mediated membrane fusion machinery
The Nobel Prize in Physiology or Medicine 2013 was awarded jointly to James E. Rothman, Randy W. Schekman and Thomas C. Südhof "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells".

Mean distance: 8.5 (cluster 21)
Cross-listing: Cell Biology Tree


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Eugene Patrick Kennedy grad student 1976 Harvard Medical School
 (Transbilayer asymmetry and its maintenance in biological membranes)
Harvey  F. Lodish post-doc 1976-1978 MIT


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Con Beckers grad student (Cell Biology Tree)
William G. Dunphy grad student Caltech
Sandra Schmid grad student Stanford (Cell Biology Tree)
John L. R. Rubenstein grad student 1980-1982 Stanford (Neurotree)
Benjamin Glick grad student 1983-1988 Stanford (Cell Biology Tree)
Tobias M. Hohl grad student 1995-2000
Daniel T. Radoff grad student 2007-2011 Columbia
Sarah M. Auclair post-doc Yale School of Medicine
William E. Balch post-doc Stanford (Cell Biology Tree)
Vivek Malhotra post-doc Stanford (Cell Biology Tree)
Gero Miesenbock post-doc Memorial Sloan Kettering (Neurotree)
Peggy J. Weidman post-doc Princeton (Neurotree)
Suzanne R. Pfeffer post-doc 1984-1985 Stanford
Martin Gerard (Gerry) Waters post-doc 1990-1992 Princeton (Cell Biology Tree)
Sidney W. Whiteheart post-doc 1994 Memorial Sloan-Kettering Cancer Center
Giampietro Schiavo post-doc 1996 Memorial Sloan-Kettering Cancer Center (Neurotree)
James A. McNew post-doc 1995-2000 Memorial Sloan-Kettering Cancer Center
Greg Lavieu post-doc 2006-2015 (Cell Biology Tree)
Erdem Karatekin research scientist 2008-2011 Yale
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Heo P, Ramakrishnan S, Coleman J, et al. (2019) Highly Reproducible Physiological Asymmetric Membrane with Freely Diffusing Embedded Proteins in a 3D-Printed Microfluidic Setup. Small (Weinheim An Der Bergstrasse, Germany). e1900725
Salpietro V, Malintan NT, Llano-Rivas I, et al. (2019) Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic Membrane Fusion and Impair Human Neurodevelopment. American Journal of Human Genetics
Erdmann RS, Baguley SW, Richens JH, et al. (2019) Labeling Strategies Matter for Super-Resolution Microscopy: A Comparison between HaloTags and SNAP-tags. Cell Chemical Biology
Manca F, Pincet F, Truskinovsky L, et al. (2019) SNARE machinery is optimized for ultrafast fusion. Proceedings of the National Academy of Sciences of the United States of America
Ramakrishnan S, Bera M, Coleman J, et al. (2018) Synaptotagmin oligomers are necessary and can be sufficient to form a Ca -sensitive fusion clamp. Febs Letters
Li X, Radhakrishnan A, Grushin K, et al. (2018) Symmetrical Organization of Proteins Under Docked Synaptic-Vesicles. Febs Letters
Ernst AM, Syed SA, Zaki O, et al. (2018) S-Palmitoylation Sorts Membrane Cargo for Anterograde Transport in the Golgi. Developmental Cell. 47: 479-493.e7
Karatekin E, Rothman JE. (2018) FEBS Letters Special Issue on Exocytosis and Endocytosis. Febs Letters. 592: 3477-3479
Kilian N, Goryaynov A, Lessard MD, et al. (2018) Assessing photodamage in live-cell STED microscopy. Nature Methods. 15: 755-756
Bello OD, Jouannot O, Chaudhuri A, et al. (2018) Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis. Proceedings of the National Academy of Sciences of the United States of America
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