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James E. Rothman

1978-1988 Biochemistry Stanford University, Palo Alto, CA 
 1988-1991 Molecular Biology Princeton University, Princeton, NJ 
 1991-2004 Cellular Biochemistry and Biophysics Memorial Sloan-Kettering Cancer Center, Rockville Centre, NY, United States 
 2004-2008 Cellular Biophysics Columbia University, New York, NY 
 2008- Cell Biology Yale University, New Haven, CT 
Secretion, membrane fusion
"James E. Rothman"
Discovered most of the eukaryotic SNARE-mediated membrane fusion machinery
The Nobel Prize in Physiology or Medicine 2013 was awarded jointly to James E. Rothman, Randy W. Schekman and Thomas C. Südhof "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells".

Mean distance: 8.5 (cluster 21)
Cross-listing: Cell Biology Tree


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Eugene Patrick Kennedy grad student 1976 Harvard Medical School
 (Transbilayer asymmetry and its maintenance in biological membranes)
Harvey F. Lodish post-doc 1976-1978 MIT


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Robert J Johnston research assistant (Neurotree)
Con Beckers grad student (Cell Biology Tree)
William G. Dunphy grad student Caltech
Sandra Schmid grad student Stanford (Cell Biology Tree)
John L. R. Rubenstein grad student 1980-1982 Stanford (Neurotree)
Benjamin Glick grad student 1983-1988 Stanford (Cell Biology Tree)
Tobias M. Hohl grad student 1995-2000
Daniel T. Radoff grad student 2007-2011 Columbia
Lena K Schroder grad student 2008-2014 Yale (Cell Biology Tree)
Sarah M. Auclair post-doc Yale School of Medicine
William E. Balch post-doc Stanford (Cell Biology Tree)
Frantz Brückert post-doc
Lara K. Mahal post-doc Sloan-Kettering
Vivek Malhotra post-doc Stanford (Cell Biology Tree)
Gero Miesenbock post-doc Memorial Sloan Kettering (Neurotree)
Abdou Rachid Thiam post-doc (Cell Biology Tree)
Peggy J. Weidman post-doc Princeton (Neurotree)
Ai Yamamoto post-doc (Neurotree)
Suzanne R. Pfeffer post-doc 1984-1985 Stanford
Michael Brunner post-doc 1989-1991 University of Heidelberg (Cell Biology Tree)
Martin Gerard (Gerry) Waters post-doc 1990-1992 Princeton (Cell Biology Tree)
Sidney W. Whiteheart post-doc 1994 Memorial Sloan-Kettering Cancer Center
Giampietro Schiavo post-doc 1996 Memorial Sloan-Kettering Cancer Center (Neurotree)
James A. McNew post-doc 1995-2000 Memorial Sloan-Kettering Cancer Center
Greg Lavieu post-doc 2006-2015 (Cell Biology Tree)
Sathish Ramakrishnan post-doc 2015-2019
Erdem Karatekin research scientist 2008-2011 Yale
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Bera M, Ramakrishnan S, Coleman J, et al. (2022) Molecular determinants of complexin clamping and activation function. Elife. 11
François-Martin C, Bacle A, Rothman JE, et al. (2021) Cooperation of Conical and Polyunsaturated Lipids to Regulate Initiation and Processing of Membrane Fusion. Frontiers in Molecular Biosciences. 8: 763115
Li F, Kalyana Sundaram V, Gatta AT, et al. (2021) Vesicle capture by membrane-bound Munc13-1 requires self-assembly into discrete clusters. Febs Letters
Hao X, Allgeyer ES, Lee DR, et al. (2021) Three-dimensional adaptive optical nanoscopy for thick specimen imaging at sub-50-nm resolution. Nature Methods
Heo P, Coleman J, Fleury JB, et al. (2021) Nascent fusion pore opening monitored at single-SNAREpin resolution. Proceedings of the National Academy of Sciences of the United States of America. 118
Radhakrishnan A, Li X, Grushin K, et al. (2021) Symmetrical arrangement of proteins under release-ready vesicles in presynaptic terminals. Proceedings of the National Academy of Sciences of the United States of America. 118
Kalyana Sundaram RV, Jin H, Li F, et al. (2020) Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly. Febs Letters
Ziltener P, Rebane AA, Graham M, et al. (2020) The golgin family exhibits a propensity to form condensates in living cells. Febs Letters
Raote I, Ernst AM, Campelo F, et al. (2020) TANGO1 membrane helices create a lipid diffusion barrier at curved membranes. Elife. 9
Ramakrishnan S, Bera M, Coleman J, et al. (2020) Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis. Elife. 9
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