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James E. Rothman

1978-1988 Biochemistry Stanford University, Palo Alto, CA 
 1988-1991 Molecular Biology Princeton University, Princeton, NJ 
 1991-2004 Cellular Biochemistry and Biophysics Memorial Sloan-Kettering Cancer Center, Rockville Centre, NY, United States 
 2004-2008 Cellular Biophysics Columbia University, New York, NY 
 2008- Cell Biology Yale University, New Haven, CT 
Secretion, membrane fusion
"James E. Rothman"

Discovered most of the eukaryotic SNARE-mediated membrane fusion machinery
The Nobel Prize in Physiology or Medicine 2013 was awarded jointly to James E. Rothman, Randy W. Schekman and Thomas C. Südhof "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells".
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Mean distance: 8.5 (cluster 21)
Cross-listing: Cell Biology Tree


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Marshall Fixman research assistant 1969-1970 Yale
Harold J. Morowitz research assistant 1970-1971 Yale
 (Senior thesis)
Eugene Patrick Kennedy grad student 1976 Harvard Medical School
 (Transbilayer asymmetry and its maintenance in biological membranes)
Harvey F. Lodish post-doc 1976-1978 MIT


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Robert J Johnston research assistant (Neurotree)
Con Beckers grad student (Cell Biology Tree)
William G. Dunphy grad student Caltech
Andreas M. Ernst grad student Yale School of Medicine (Cell Biology Tree)
Sandra Schmid grad student Stanford (Cell Biology Tree)
John L. R. Rubenstein grad student 1980-1982 Stanford (Neurotree)
Benjamin Glick grad student 1983-1988 Stanford (Cell Biology Tree)
Tobias M. Hohl grad student 1995-2000
Daniel T. Radoff grad student 2007-2011 Columbia
Lena K Schroder grad student 2008-2014 Yale (Cell Biology Tree)
Sarah M. Auclair post-doc Yale School of Medicine
William E. Balch post-doc Stanford (Cell Biology Tree)
Frantz Brückert post-doc
Lara K. Mahal post-doc Sloan-Kettering
Vivek Malhotra post-doc Stanford (Cell Biology Tree)
Gero Miesenbock post-doc Memorial Sloan Kettering (Neurotree)
Abdou Rachid Thiam post-doc (Cell Biology Tree)
Peggy J. Weidman post-doc Princeton (Neurotree)
Ai Yamamoto post-doc (Neurotree)
Suzanne R. Pfeffer post-doc 1984-1985 Stanford
Michael Brunner post-doc 1989-1991 Heidelberg University (Cell Biology Tree)
Martin Gerard (Gerry) Waters post-doc 1990-1992 Princeton (Cell Biology Tree)
Sidney W. Whiteheart post-doc 1994 Memorial Sloan-Kettering Cancer Center
Giampietro Schiavo post-doc 1996 Memorial Sloan-Kettering Cancer Center (Neurotree)
James A. McNew post-doc 1995-2000 Memorial Sloan-Kettering Cancer Center
Greg Lavieu post-doc 2006-2015 (Cell Biology Tree)
Sathish Ramakrishnan post-doc 2015-2019
Erdem Karatekin research scientist 2008-2011 Yale
BETA: Related publications


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Bera M, Radhakrishnan A, Coleman J, et al. (2023) Synaptophysin chaperones the assembly of 12 SNAREpins under each ready-release vesicle. Proceedings of the National Academy of Sciences of the United States of America. 120: e2311484120
Kalyana Sundaram RV, Chatterjee A, Bera M, et al. (2023) Roles for diacylglycerol in synaptic vesicle priming and release revealed by complete reconstitution of core protein machinery. Proceedings of the National Academy of Sciences of the United States of America. 120: e2309516120
Bera M, Grushin K, Sundaram RVK, et al. (2023) Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release. Biorxiv : the Preprint Server For Biology
Bera M, Radhakrishnan A, Coleman J, et al. (2023) Synaptophysin Chaperones the Assembly of 12 SNAREpins under each Ready-Release Vesicle. Biorxiv : the Preprint Server For Biology
Sundaram RVK, Chatterjee A, Bera M, et al. (2023) Novel Roles for Diacylglycerol in Synaptic Vesicle Priming and Release Revealed by Complete Reconstitution of Core Protein Machinery. Biorxiv : the Preprint Server For Biology
Panda A, Giska F, Duncan AL, et al. (2023) Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer. Nature Methods
Rothman JE. (2022) The gripping story of integrins. Cell
Zhu J, McDargh ZA, Li F, et al. (2022) Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208337119
Bera M, Ramakrishnan S, Coleman J, et al. (2022) Molecular determinants of complexin clamping and activation function. Elife. 11
Grushin K, Kalyana Sundaram RV, Sindelar CV, et al. (2022) Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release. Proceedings of the National Academy of Sciences of the United States of America. 119
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