Elyse Bourque, Ph.D.

Affiliations: 
Université de Sherbrooke, Sherbrooke, Québec, Canada 
Area:
Organic Chemistry
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"Elyse Bourque"
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Pierre Deslongchamps grad student 2001 Université de Sherbrooke
 (Etude de la reaction de Diels -Alder transannulaire de macrocycles a quatorze membres de geometrie trans-trans-trans comportant un dienophile active ou non-active.)
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Publications

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Arns S, Tan J, Sun S, et al. (2015) Assessing the oral bioavailability of difluorosialic acid prodrugs, potent viral neuraminidase inhibitors, using a snapshot PK screening assay. Bioorganic & Medicinal Chemistry Letters. 25: 2505-9
Skerlj R, Bridger G, Zhou Y, et al. (2013) Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: potent inhibitors of R5 HIV-1 replication. Journal of Medicinal Chemistry. 56: 8049-65
Skerlj R, Bridger G, Zhou Y, et al. (2012) Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication. Acs Medicinal Chemistry Letters. 3: 216-21
Skerlj R, Bridger G, Zhou Y, et al. (2011) Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication. Bioorganic & Medicinal Chemistry Letters. 21: 6950-4
Metz M, Bourque E, Labrecque J, et al. (2011) Prospective CCR5 small molecule antagonist compound design using a combined mutagenesis/modeling approach. Journal of the American Chemical Society. 133: 16477-85
Skerlj R, Bridger G, Zhou Y, et al. (2011) Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication. Bioorganic & Medicinal Chemistry Letters. 21: 2450-5
Bourque E, Kocienski PJ, Stocks M, et al. (2005) Synthesis of the C14-C28 fragment of tetronasin Synthesis. 3219-3224
Kocienski P, Bell R, Bourque E, et al. (2004) Synthetic applications of planar chiral cationic η 3-allylmolybdenum complexes Pure and Applied Chemistry. 76: 477-494
Bourque E, Deslongchamps P, Dory YL. (2003) First experimental and theoretical evidence of a deactivating enone dienophile in the transannular Diels-Alder reaction. The Journal of Organic Chemistry. 68: 2390-7
Phoenix S, Bourque E, Deslongchamps P. (2000) Progress toward the total synthesis of cassaine via the transannular diels-alder strategy Organic Letters. 2: 4149-52
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