Olivier Lepage, Ph.D.

Affiliations: 
Université de Sherbrooke, Sherbrooke, Québec, Canada 
Area:
Organic Chemistry
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"Olivier Lepage"
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Pierre Deslongchamps grad student 2003 Université de Sherbrooke
 (Developpement d'une approche de synthese de steroides utilisant un nouveau type de reactif de Nazarov.)
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Publications

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Hucke O, Coulombe R, Bonneau P, et al. (2014) Molecular dynamics simulations and structure-based rational design lead to allosteric HCV NS5B polymerase thumb pocket 2 inhibitor with picomolar cellular replicon potency. Journal of Medicinal Chemistry. 57: 1932-43
Beaulieu PL, Coulombe R, Duan J, et al. (2013) Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype. Bioorganic & Medicinal Chemistry Letters. 23: 4132-40
Goudreau N, Hucke O, Faucher AM, et al. (2013) Discovery and structural characterization of a new inhibitor series of HIV-1 nucleocapsid function: NMR solution structure determination of a ternary complex involving a 2:1 inhibitor/NC stoichiometry. Journal of Molecular Biology. 425: 1982-98
Ramachandran SA, Kharul RK, Lepage O, et al. (2006) Synthetic studies toward highly functionalized 5beta-lanosterol derivatives: a versatile approach utilizing anionic cycloaddition. The Journal of Organic Chemistry. 71: 6149-56
Lepage O, Kattnig E, Fürstner A. (2004) Total synthesis of amphidinolide X. Journal of the American Chemical Society. 126: 15970-1
Lepage O, Deslongchamps P. (2003) New strategy for convergent steroid synthesis. The Journal of Organic Chemistry. 68: 2183-6
Lepage O, Stone C, Deslongchamps P. (2002) Nazarov reagents for convergent and expedient synthesis of new steroids. Organic Letters. 4: 1091-4
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