Jakob Begun, Ph.D.

Harvard University, Cambridge, MA, United States 
Molecular Biology
"Jakob Begun"
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Fred M. Ausubel grad student 2005 Harvard
 (Investigating the host -pathogen interaction using a Staphylococcus-Caenorhabditis elegans model system.)
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Gulhane M, Murray L, Lourie R, et al. (2016) High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22. Scientific Reports. 6: 28990
Lassen KG, McKenzie CI, Mari M, et al. (2016) Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Immunity
Begun J, Lassen KG, Jijon HB, et al. (2015) Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy Cell Reports. 11: 1905-1918
de Luca A, Smeekens SP, Casagrande A, et al. (2014) IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proceedings of the National Academy of Sciences of the United States of America. 111: 3526-31
Begun J, Xavier RJ. (2013) Autophagy at the crossroads of metabolism and cellular defense. Current Opinion in Gastroenterology. 29: 588-96
Beaudoin M, Goyette P, Boucher G, et al. (2013) Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. Plos Genetics. 9: e1003723
Huett A, Heath RJ, Begun J, et al. (2012) The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium. Cell Host & Microbe. 12: 778-90
Miyata S, Begun J, Troemel ER, et al. (2008) DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics. 178: 903-18
Begun J, Gaiani JM, Rohde H, et al. (2007) Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses. Plos Pathogens. 3: e57
Sifri CD, Begun J, Ausubel FM. (2005) The worm has turned--microbial virulence modeled in Caenorhabditis elegans. Trends in Microbiology. 13: 119-27
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