Wesley R. Legant, Ph.D.

Affiliations: 
Bioengineering University of Pennsylvania, Philadelphia, PA, United States 
Area:
Tissue Microfabrication
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Christopher S. Chen grad student 2012 Penn (BME Tree)
 (Microscale measurements of cell and tissue mechanics in three dimensions.)
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Publications

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Doherty EL, Aw WY, Warren EC, et al. (2023) Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics. Acta Biomaterialia
Hakeem RM, Subramanian BC, Hockenberry MA, et al. (2022) A Photopolymerized Hydrogel System with Dual Stiffness Gradients Reveals Distinct Actomyosin-Based Mechano-Responses in Fibroblast Durotaxis. Acs Nano
Hockenberry MA, Legant WR. (2022) Cells in the mechanical spotlight. Biophysical Journal. 121: 3571-3572
Xie L, Dong P, Chen X, et al. (2020) 3D ATAC-PALM: super-resolution imaging of the accessible genome. Nature Methods
O'Shaughnessy EC, Stone OJ, LaFosse PK, et al. (2019) Software for lattice light-sheet imaging of FRET biosensors, illustrated with a new Rap1 biosensor. The Journal of Cell Biology
David AF, Roudot P, Legant WR, et al. (2019) Augmin accumulation on long-lived microtubules drives amplification and kinetochore-directed growth. The Journal of Cell Biology
Valm AM, Cohen S, Legant WR, et al. (2017) Applying systems-level spectral imaging and analysis to reveal the organelle interactome. Nature
Aguet F, Upadhyayula S, Gaudin R, et al. (2016) Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Molecular Biology of the Cell
Li L, Liu H, Dong P, et al. (2016) Real-time imaging of Huntingtin aggregates diverting target search and gene transcription. Elife. 5
Imhof S, Fragoso C, Hemphill A, et al. (2016) Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication? F1000research. 5: 682
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