Philip D. Mosier, Ph.D.

Pennsylvania State University, State College, PA, United States 
Computational Chemistry
"Philip Mosier"
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Peter C. Jurs grad student 2003 Penn State
 (Prediction of chemical properties and biological activities of organic compounds from molecular structure and use of probabilistic and generalized regression neural networks.)
Umesh R. Desai post-doc 2009-2011 VCU
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Chiang MJ, Musayev FN, Kosikova M, et al. (2017) Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication. Emerging Microbes & Infections. 6: e108
Sankarayanarayanan NV, Strebel TR, Boothello RS, et al. (2017) A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II. Angewandte Chemie (International Ed. in English)
Mosier PD, Chiang MJ, Lin Z, et al. (2016) Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1. Scientific Reports. 6: 32340
Sarkar A, Yu W, Desai UR, et al. (2016) Estimating glycosaminoglycan-protein interaction affinity: Water dominates the specific antithrombin-heparin interaction. Glycobiology
Joseph PR, Mosier PD, Desai UR, et al. (2015) Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions. The Biochemical Journal. 472: 121-33
Vardy E, Sassano MF, Rennekamp AJ, et al. (2015) Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chemistry & Biology. 22: 764-75
Vardy E, Robinson JE, Li C, et al. (2015) A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 86: 936-46
Yuan Y, Zaidi SA, Stevens DL, et al. (2015) Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands. Bioorganic & Medicinal Chemistry. 23: 1701-15
Sakloth F, Kolanos R, Mosier PD, et al. (2015) Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para-substituted methcathinone analogues. British Journal of Pharmacology. 172: 2210-8
Sankaranarayanan NV, Sarkar A, Desai UR, et al. (2015) Designing "high-affinity, high-specificity" glycosaminoglycan sequences through computerized modeling. Methods in Molecular Biology (Clifton, N.J.). 1229: 289-314
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