Emily K. Osterweil, Ph.D.

Affiliations: 
Yale University, New Haven, CT 
Area:
cytoskeleton. Epithelial cell biology. molecular motors
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SNBCP

Parents

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Mark S. Mooseker grad student 2005 Yale
 (Myosin VI and myosin Ie in postsynaptic function.)
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Publications

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Barnes SA, Wijetunge LS, Jackson AD, et al. (2015) Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15073-81
Sidorov MS, Kaplan ES, Osterweil EK, et al. (2015) Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex. Proceedings of the National Academy of Sciences of the United States of America
Till SM, Asiminas A, Jackson AD, et al. (2015) Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS. Human Molecular Genetics
Sidorov MS, Krueger DD, Taylor M, et al. (2014) Extinction of an instrumental response: a cognitive behavioral assay in Fmr1 knockout mice. Genes, Brain, and Behavior
Lohith TG, Osterweil EK, Fujita M, et al. (2013) Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome? Molecular Autism. 4: 15
Osterweil EK, Chuang SC, Chubykin AA, et al. (2013) Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome. Neuron. 77: 243-50
Osterweil EK, Kind PC, Bear MF. (2012) Lifting the mood on treating fragile X. Biological Psychiatry. 72: 895-7
Auerbach BD, Osterweil EK, Bear MF. (2011) Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature. 480: 63-8
Krueger DD, Osterweil EK, Chen SP, et al. (2011) Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome. Proceedings of the National Academy of Sciences of the United States of America. 108: 2587-92
Osterweil EK, Krueger DD, Reinhold K, et al. (2010) Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15616-27
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