Ariele Giorgio Viacava Follis

Structural Biology St. Jude Children's Research Hospital, San Francisco, CA, United States 
protein structure-function, intrinsically disordered proteins, protein-protein interactions, chemical biology, tumor suppression
"Ariele Giorgio Viacava Follis"
Viacava Follis, Ariele Giorgio G., Exploiting Structural Disorder to Enhance Small Molecule Inhibition of the Oncoprotein c-Myc DImerization with its Partner Max, thesis Georgetown University, 2009

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Steven J. Metallo grad student 2009 Georgetown
 (Exploiting structural disorder to enhance small molecule inhibition of the oncoprotein c-Myc dimerization with its partner Max.)
Richard W. Kriwacki post-doc St. Jude Children's Research Hospital
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Csizmok V, Follis AV, Kriwacki RW, et al. (2016) Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling. Chemical Reviews
Zheng J, Viacava Follis A, Kriwacki RW, et al. (2015) Discoveries and Controversies in BCL-2 Proteins-Mediated Apoptosis. The Febs Journal
Follis AV, Llambi F, Merritt P, et al. (2015) Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis. Molecular Cell. 59: 677-84
Follis AV, Llambi F, Ou L, et al. (2014) The DNA-binding domain mediates both nuclear and cytosolic functions of p53. Nature Structural & Molecular Biology. 21: 535-43
Hammoudeh DI, Daté M, Yun MK, et al. (2014) Identification and characterization of an allosteric inhibitory site on dihydropteroate synthase. Acs Chemical Biology. 9: 1294-302
Moldoveanu T, Follis AV, Kriwacki RW, et al. (2014) Many players in BCL-2 family affairs. Trends in Biochemical Sciences. 39: 101-11
Follis AV, Chipuk JE, Fisher JC, et al. (2013) PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nature Chemical Biology. 9: 163-8
Follis AV, Galea CA, Kriwacki RW. (2012) Intrinsic protein flexibility in regulation of cell proliferation: advantages for signaling and opportunities for novel therapeutics. Advances in Experimental Medicine and Biology. 725: 27-49
Hammoudeh DI, Follis AV, Prochownik EV, et al. (2009) Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-Myc. Journal of the American Chemical Society. 131: 7390-401
Mustata G, Follis AV, Hammoudeh DI, et al. (2009) Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model. Journal of Medicinal Chemistry. 52: 1247-50
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