Kevin J. Frankowski, Ph.D.

Affiliations: 
University of Delaware, Newark, DE, United States 
Area:
Stereoselective synthesis of natural products; New methods in synthetic organic chemistry; Computational organometa llic chemistry
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Douglass F. Taber grad student 2006 University of Delaware
 (Carbenes and carbenoids as powerful tools in organic synthesis.)
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Publications

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Moritz AE, Free RB, Weiner WS, et al. (2020) Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. Journal of Medicinal Chemistry
Luderman KD, Conroy JL, Free RB, et al. (2018) Identification of positive allosteric modulators of the D1 dopamine receptor that act at diverse binding sites. Molecular Pharmacology
Chun LS, Vekariya RH, Free RB, et al. (2018) Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the DDopamine Receptor. Frontiers in Synaptic Neuroscience. 10: 2
McLeod MC, Aubé J, Frankowski KJ. (2016) Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples. Bioorganic & Medicinal Chemistry Letters
Scarry SM, Lovell KM, Frankowski KJ, et al. (2016) Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-alpha]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence. The Journal of Organic Chemistry
Luderman KD, Conroy JL, Free RB, et al. (2016) Structurally Diverse Positive Allosteric Modulators of the D1 Dopamine Receptor Potentiate G‐Protein and β‐Arrestin‐Mediated Signaling The Faseb Journal. 30
He S, Jain P, Lin B, et al. (2015) High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors. Acs Combinatorial Science
Morgenweck J, Frankowski KJ, Prisinzano TE, et al. (2015) Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus. Neuropharmacology
Zhou L, Stahl EL, Lovell KM, et al. (2015) Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting. Neuropharmacology
Sweeney NL, Hanson AM, Mukherjee S, et al. (2015) Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase. Acs Infectious Diseases. 1: 140-148
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