Daniel M. Bowles, Ph.D.

Affiliations: 
University of Kentucky, Lexington, KY 
Area:
organic chemistry, materials chemistry
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"Daniel Bowles"
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John Edward Anthony grad student 2001 University of Kentucky
 (Reiterative cycloaromatization in the synthesis of polycyclic aromatic hydrocarbons.)
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Publications

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Blackburn A, Bowles DM, Curran TT, et al. (2012) Air oxidation of N-cyclopropylanilines Synthetic Communications. 42: 1855-1863
Pfefferkorn JA, Litchfield J, Hutchings R, et al. (2011) Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution. Bioorganic & Medicinal Chemistry Letters. 21: 2725-31
Huang Q, Richardson PF, Sach NW, et al. (2011) Development of scalable syntheses of selective PI3K inhibitors Organic Process Research and Development. 15: 556-564
Bowles DM, Boyles DC, Choi C, et al. (2011) Development of an early enabling synthesis for PF-03052334-02: A novel hepatoselective HMG-CoA reductase inhibitor Organic Process Research and Development. 15: 148-157
Boos C, Bowles DM, Cai C, et al. (2011) Synthesis and cross coupling of a highly substituted 2-pyridylboronate: Application to the large scale synthesis of a mineralocorticoid antagonist Tetrahedron Letters. 52: 7025-7029
Chen R, Bowles D, Antosz F, et al. (2011) Practical approaches in applying Process Analytical Technology (PAT) tools to early Active Pharmaceutical Ingredient (API) development Pharmaceutical Outsourcing. 12: 28-33
Magano J, Bowles D, Conway B, et al. (2009) Diastereoselective, large-scale synthesis of β-amino acids via asymmetric aza-Michael addition as α2δ ligands for the treatment of generalized anxiety disorder and insomnia Tetrahedron Letters. 50: 6325-6328
Magano J, Conway B, Bowles D, et al. (2009) Diastereoselective, large scale synthesis of β-amino acids via asymmetric enamide hydrogenation as α2δ ligands for the treatment of generalized anxiety disorder and insomnia Tetrahedron Letters. 50: 6329-6331
Chandrasekaran P, Donahue JP, Bowles DM, et al. (2009) Synthesis of 4,5-Dimethyl-1,3-dithiol-2-one Organic Syntheses. 86: 333-343
Bowles DM, Bolton GL, Boyles DC, et al. (2008) Preparation of a HMG-CoA reductase inhibitor via an optimized imidazole-forming condensation reaction Organic Process Research and Development. 12: 1183-1187
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