Andrew S. Murkin, Ph.D.

University of British Columbia, Vancouver, Vancouver, BC, Canada 
Studies on novel enzyme mechanisms; epimerases and racemases; sugar nucleotide-modifying enzymes; isotope effects; inhibitor design; site-directed mutagenesis
"Andrew Murkin"
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Martin E. Tanner grad student 2004 UBC
 (Mechanistic investigations of enzyme-catalyzed peptide and carbohydrate epimerization.)
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Murkin AS. (2015) Commentary: Ohm's law as an analogy for enzyme kinetics. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. 43: 139-41
Kholodar SA, Allen CL, Gulick AM, et al. (2015) The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in pieces. Journal of the American Chemical Society. 137: 2748-56
Murkin AS, Manning KA, Kholodar SA. (2014) Mechanism and inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Bioorganic Chemistry. 57: 171-85
Kholodar SA, Tombline G, Liu J, et al. (2014) Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin. Biochemistry. 53: 3423-31
Moynihan MM, Murkin AS. (2014) Cysteine is the general base that serves in catalysis by isocitrate lyase and in mechanism-based inhibition by 3-nitropropionate. Biochemistry. 53: 178-87
Murkin AS, Moynihan MM. (2014) Transition-state-guided drug design for treatment of parasitic neglected tropical diseases. Current Medicinal Chemistry. 21: 1781-93
Kholodar SA, Murkin AS. (2013) DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group. Biochemistry. 52: 2302-8
Manning KA, Sathyamoorthy B, Eletsky A, et al. (2012) Highly precise measurement of kinetic isotope effects using 1H-detected 2D [13C,1H]-HSQC NMR spectroscopy. Journal of the American Chemical Society. 134: 20589-92
Liu J, Murkin AS. (2012) Pre-steady-state kinetic analysis of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Mycobacterium tuberculosis reveals partially rate-limiting product release by parallel pathways. Biochemistry. 51: 5307-19
Cassera MB, Hazleton KZ, Merino EF, et al. (2011) Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. Plos One. 6: e26916
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