David V. Smil, Ph.D.
Affiliations: | University of Toronto, Toronto, ON, Canada |
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"David Smil"Mean distance: 8.94 | S | N | B | C | P |
Parents
Sign in to add mentor| Robert A. Batey | grad student | 2001 | University of Toronto | |
| (Boron tethered radical cyclizations and potassium organotrifluoroborates in organic synthesis.) | ||||
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Publications
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| Smil D, Wong JF, Williams E, et al. (2020) Leveraging an Open Science Drug Discovery Model to Develop CNS Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. Journal of Medicinal Chemistry |
| Ensan D, Smil D, Zepeda-Velázquez CA, et al. (2020) Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. Journal of Medicinal Chemistry |
| Mader P, Mendoza-Sanchez R, Iqbal A, et al. (2019) Identification and characterization of the first fragment hits for SETDB1 Tudor domain. Bioorganic & Medicinal Chemistry |
| Kaniskan HÜ, Eram MS, Zhao K, et al. (2017) Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Journal of Medicinal Chemistry |
| Kaniskan HÜ, Eram MS, Liu J, et al. (2016) Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1). Medchemcomm. 7: 1793-1796 |
| Hughes SJ, Barnard L, Mottaghi K, et al. (2016) Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product. Acs Infectious Diseases. 2: 627-641 |
| Shen Y, Szewczyk MM, Eram MS, et al. (2016) Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. Journal of Medicinal Chemistry |
| Ferreira de Freitas R, Eram MS, Smil D, et al. (2016) Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. Journal of Medicinal Chemistry |
| Gilan O, Lam EY, Becher I, et al. (2016) Functional interdependence of BRD4 and DOT1L in MLL leukemia. Nature Structural & Molecular Biology |
| Getlik M, Smil D, Zepeda-Velázquez C, et al. (2016) Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). Journal of Medicinal Chemistry |