David V. Smil, Ph.D.

University of Toronto, Toronto, ON, Canada 
"David Smil"
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Robert A. Batey grad student 2001 University of Toronto
 (Boron tethered radical cyclizations and potassium organotrifluoroborates in organic synthesis.)
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Shen Y, Szewczyk MM, Eram MS, et al. (2016) Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. Journal of Medicinal Chemistry
Ferreira de Freitas R, Eram MS, Smil D, et al. (2016) Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. Journal of Medicinal Chemistry
Gilan O, Lam EY, Becher I, et al. (2016) Functional interdependence of BRD4 and DOT1L in MLL leukemia. Nature Structural & Molecular Biology
Getlik M, Smil D, Zepeda-Velázquez C, et al. (2016) Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). Journal of Medicinal Chemistry
Ferreira de Freitas R, Eram MS, Szewczyk MM, et al. (2016) Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. Journal of Medicinal Chemistry
Davydov R, Strushkevich N, Smil D, et al. (2015) Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. Biochemistry
Grebien F, Vedadi M, Getlik M, et al. (2015) Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nature Chemical Biology. 11: 571-8
Smil D, Eram MS, Li F, et al. (2015) Discovery of a Dual PRMT5-PRMT7 Inhibitor. Acs Medicinal Chemistry Letters. 6: 408-12
Kaniskan HÜ, Szewczyk MM, Yu Z, et al. (2015) A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International Ed. in English). 54: 5166-70
Liu F, Li F, Ma A, et al. (2013) Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. Journal of Medicinal Chemistry. 56: 2110-24
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