John E. Weldon, Ph.D.
Affiliations: | Johns Hopkins University, Baltimore, MD |
Area:
biochemical and biophysical principles involved in protein functionGoogle:
"John Weldon"Mean distance: 10.55
Parents
Sign in to add mentor| Robert F. Schleif | grad student | 2006 | Johns Hopkins | |
| (Understanding and manipulating the AraC "beta-kiss" interaction.) | ||||
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Publications
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| Zhu Y, Weldon JE. (2019) Evaluating the influence of common antibiotics on the efficacy of a recombinant immunotoxin in tissue culture. Bmc Research Notes. 12: 293 |
| Hobson JJ, Gallegos AS, Atha BW, et al. (2018) Investigation of amino acid specificity in the CydX small protein shows sequence plasticity at the functional level. Plos One. 13: e0198699 |
| Weldon JE, Skarzynski M, Therres JA, et al. (2015) Designing the furin-cleavable linker in recombinant immunotoxins based on Pseudomonas exotoxin A. Bioconjugate Chemistry. 26: 1120-8 |
| Weldon JE, Xiang L, Zhang J, et al. (2013) A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity. Molecular Cancer Therapeutics. 12: 48-57 |
| Mazor R, Vassall AN, Eberle JA, et al. (2012) Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A. Proceedings of the National Academy of Sciences of the United States of America. 109: E3597-603 |
| Liu W, Onda M, Kim C, et al. (2012) A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity. Protein Engineering, Design & Selection : Peds. 25: 1-6 |
| Weldon JE, Pastan I. (2011) A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer. The Febs Journal. 278: 4683-700 |
| Pastan I, Onda M, Weldon J, et al. (2011) Immunotoxins with decreased immunogenicity and improved activity. Leukemia & Lymphoma. 52: 87-90 |
| Onda M, Beers R, Xiang L, et al. (2011) Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 108: 5742-7 |
| Hansen JK, Weldon JE, Xiang L, et al. (2010) A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice. Journal of Immunotherapy (Hagerstown, Md. : 1997). 33: 297-304 |