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Karen E. Jennette Wetterhahn

Dartmouth College, Hanover, NH, United States 
Toxic Metals
"Karen E. Wetterhahn"

(1948 - 1997)
Karen Wetterhahn became ill and died in 1997, at the age of 48, as a result of a tragic laboratory accident involving a highly toxic mercury compound.

Mean distance: 7.45


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Stephen James Lippard grad student 1975 Columbia
 (Metallointercalation reagents : synthesis, physical properties and their interaction with nucleic acids)
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Yuann JM, Liu KJ, Hamilton JW, et al. (1999) In vivo effects of ascorbate and glutathione on the uptake of chromium, formation of chromium(V), chromium-DNA binding and 8-hydroxy-2'-deoxyguanosine in liver and kidney of osteogenic disorder shionogi rats following treatment with chromium(VI). Carcinogenesis. 20: 1267-75
Dubrovskaya VA, Wetterhahn KE. (1998) Effects of Cr(VI) on the expression of the oxidative stress genes in human lung cells. Carcinogenesis. 19: 1401-7
Shumilla JA, Wetterhahn KE, Barchowsky A. (1998) Inhibition of NF-κB binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro: Evidence of a thiol mechanism Archives of Biochemistry and Biophysics. 349: 356-362
Wilker JJ, Wetterhahn KE, Lippard SJ. (1997) Methyl Transfer to Mercury Thiolates: Effects of Coordination Number and Ligand Dissociation. Inorganic Chemistry. 36: 2079-2083
Sugden KD, Wetterhahn KE. (1997) Direct and hydrogen peroxide-induced chromium(V) oxidation of deoxyribose in single-stranded and double-stranded calf thymus DNA Chemical Research in Toxicology. 10: 1397-1406
Stearns DM, Wetterhahn KE. (1997) Intermediates produced in the reaction of chromium(VI) with dehydroascorbate cause single-strand breaks in plasmid DNA. Chemical Research in Toxicology. 10: 271-8
Sugden KD, Wetterhahn KE. (1996) EPR Evidence for Chromium(V) Binding to Phosphate and Pyrophosphate: Implications for Chromium(V)-DNA Interactions. Inorganic Chemistry. 35: 3727-3728
Brauer SL, Hneihen AS, McBride JS, et al. (1996) Chromium(VI) Forms Thiolate Complexes with gamma-Glutamylcysteine, N-Acetylcysteine, Cysteine, and the Methyl Ester of N-Acetylcysteine. Inorganic Chemistry. 35: 373-381
Barchowsky A, Dudek EJ, Treadwell MD, et al. (1996) Arsenic induces oxidant stress and NF-κB activation in cultured aortic endothelial cells Free Radical Biology and Medicine. 21: 783-790
Costa M, Zhitkovich A, Gargas M, et al. (1996) Interlaboratory validation of a new assay for DNA-protein crosslinks. Mutation Research. 369: 13-21
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