Karen E. Jennette Wetterhahn
Affiliations: | Dartmouth College, Hanover, NH, United States |
Area:
Toxic MetalsWebsite:
https://sites.dartmouth.edu/toxmetal/about-us/a-tribute-to-karen-wetterhahn/Google:
"Karen E. Wetterhahn"Bio:
(1948 - 1997)
http://www.chm.bris.ac.uk/motm/dimethylmercury/dmmh.htm
Karen Wetterhahn became ill and died in 1997, at the age of 48, as a result of a tragic laboratory accident involving a highly toxic mercury compound.
Mean distance: 7.45 | S | N | B | C | P |
Parents
Sign in to add mentor| Stephen James Lippard | grad student | 1975 | Columbia | |
| (Metallointercalation reagents : synthesis, physical properties and their interaction with nucleic acids) | ||||
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Publications
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| Yuann JM, Liu KJ, Hamilton JW, et al. (1999) In vivo effects of ascorbate and glutathione on the uptake of chromium, formation of chromium(V), chromium-DNA binding and 8-hydroxy-2'-deoxyguanosine in liver and kidney of osteogenic disorder shionogi rats following treatment with chromium(VI). Carcinogenesis. 20: 1267-75 |
| Wilker JJ, Wetterhahn KE, Lippard SJ. (1997) Methyl Transfer to Mercury Thiolates: Effects of Coordination Number and Ligand Dissociation. Inorganic Chemistry. 36: 2079-2083 |
| Sugden KD, Wetterhahn KE. (1997) Direct and hydrogen peroxide-induced chromium(V) oxidation of deoxyribose in single-stranded and double-stranded calf thymus DNA Chemical Research in Toxicology. 10: 1397-1406 |
| Costa M, Zhitkovich A, Gargas M, et al. (1996) Interlaboratory validation of a new assay for DNA-protein crosslinks. Mutation Research. 369: 13-21 |
| Stearns DM, Kennedy LJ, Courtney KD, et al. (1995) Reduction of chromium(VI) by ascorbate leads to chromium-DNA binding and DNA strand breaks in vitro. Biochemistry. 34: 910-9 |
| Alcedo JA, Misra M, Hamilton JW, et al. (1994) The genotoxic carcinogen chromium(VI) alters the metal-inducible expression but not the basal expression of the metallothionein gene in vivo. Carcinogenesis. 15: 1089-92 |
| Misra M, Alcedo JA, Wetterhahn KE. (1994) Two pathways for chromium(VI)-induced DNA damage in 14 day chick embryos: Cr-DNA binding in liver and 8-oxo-2'-deoxyguanosine in red blood cells. Carcinogenesis. 15: 2911-7 |
| Stearns DM, Courtney KD, Giangrande PH, et al. (1994) Chromium(VI) reduction by ascorbate: role of reactive intermediates in DNA damage in vitro. Environmental Health Perspectives. 102: 21-5 |
| Hamilton JW, Bement WJ, Sinclair PR, et al. (1992) Inhibition of protein synthesis increases the transcription of the phenobarbital-inducible CYP2H1 and CYP2H2 genes in chick embryo hepatocytes. Archives of Biochemistry and Biophysics. 298: 96-104 |
| Hamilton JW, Bement WJ, Sinclair PR, et al. (1991) Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription. Archives of Biochemistry and Biophysics. 289: 387-92 |