Ravi R. Iyer

Affiliations: 
2001-2013 Biochemistry Duke University Medical School, Durham, NC, United States 
 2013-2017 Lead Discovery & Profiling Teva Pharmaceuticals, USA 
 2017-2021 Drug Discovery & Protein Function CHDI Foundation 
 2021-2022 Drug Discovery Research Seed Therapeutics 
 2022- CSO, Script Biosciences Script Biosciences 
Area:
DNA repair, Human genetic diseases; Neurodegenerative disease, Cancer, Drug Discovery; Huntington's disease
Google:
"Ravi Iyer"
Mean distance: 8.97
 
SNBCP
BETA: Related publications

Publications

You can help our author matching system! If you notice any publications incorrectly attributed to this author, please sign in and mark matches as correct or incorrect.

Iyer RR, Pluciennik A. (2021) DNA Mismatch Repair and its Role in Huntington's Disease. Journal of Huntington's Disease. 10: 75-94
Genschel J, Kadyrova LY, Iyer RR, et al. (2017) Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair. Proceedings of the National Academy of Sciences of the United States of America
Iyer RR, Pluciennik A, Napierala M, et al. (2015) DNA triplet repeat expansion and mismatch repair. Annual Review of Biochemistry. 84: 199-226
Lindsey-Boltz LA, Kemp MG, Reardon JT, et al. (2014) Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. The Journal of Biological Chemistry. 289: 5074-82
Pluciennik A, Burdett V, Baitinger C, et al. (2013) Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 12277-82
Tseng Q, Orans J, Hast MA, et al. (2011) Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 947-52
Orans J, McSweeney EA, Iyer RR, et al. (2011) Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell. 145: 212-23
Pluciennik A, Dzantiev L, Iyer RR, et al. (2010) PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair. Proceedings of the National Academy of Sciences of the United States of America. 107: 16066-71
Iyer RR, Pluciennik A, Genschel J, et al. (2010) MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. The Journal of Biological Chemistry. 285: 11730-9
Zhao J, Jain A, Iyer RR, et al. (2009) Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks. Nucleic Acids Research. 37: 4420-9
See more...