Alykhan F. Shamji, Ph.D.

Harvard University, Cambridge, MA, United States 
Chemical biology
"Alykhan Shamji"
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Stuart L. Schreiber grad student 2005 Harvard
 (Characterization of the TOR pathway using small molecules and genomics.)
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Oberlick EM, Rees MG, Seashore-Ludlow B, et al. (2019) Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Reports. 28: 2331-2344.e8
Raj L, Ide T, Gurkar AU, et al. (2018) Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature
Subramanian A, Narayan R, Corsello SM, et al. (2017) A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell. 171: 1437-1452.e17
Leshchiner ES, Rush JS, Durney MA, et al. (2017) Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America. 114: 11392-11397
Johannessen L, Sundberg TB, O'Connell DJ, et al. (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nature Chemical Biology
Viswanathan VS, Ryan MJ, Dhruv HD, et al. (2017) Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature
Bray MA, Gustafsdottir SM, Ljosa V, et al. (2017) A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay. Gigascience
Law JM, Stark SC, Liu K, et al. (2016) Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1. Acs Medicinal Chemistry Letters. 7: 944-949
Gerhard DS, Clemons PA, Shamji AF, et al. (2016) Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Molecular Cancer Research : McR
Hong AL, Tseng YY, Cowley GS, et al. (2016) Integrated genetic and pharmacologic interrogation of rare cancers. Nature Communications. 7: 11987
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