Lance D. Langston, Ph.D.
Affiliations: | Columbia University, New York, NY |
Area:
Genetics and biochemistry of DNA recombination and repair in yeastGoogle:
"Lance Langston"Mean distance: 7962.6
Parents
Sign in to add mentorLorraine S. Symington | grad student | 2005 | Columbia | |
(Opposing roles for DNA structure -specific proteins Rad1, Msh2, Msh3 and Sgs1 in yeast gene targeting.) |
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Publications
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Langston LD, Georgescu RE, O'Donnell ME. (2023) Mechanism of eukaryotic origin unwinding is a dual helicase DNA shearing process. Proceedings of the National Academy of Sciences of the United States of America. 120: e2316466120 |
Langston LD, Yuan Z, Georgescu R, et al. (2022) SV40 T-antigen uses a DNA shearing mechanism to initiate origin unwinding. Proceedings of the National Academy of Sciences of the United States of America. 119: e2216240119 |
Langston LD, O'Donnell ME. (2019) An explanation for origin unwinding in eukaryotes. Elife. 8 |
Mayle R, Langston L, Molloy KR, et al. (2018) Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression. Proceedings of the National Academy of Sciences of the United States of America |
Langston LD, Mayle R, Schauer GD, et al. (2017) Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks. Elife. 6 |
Langston LD, O'Donnell ME. (2017) Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase. Elife. 6 |
Langston LD, Mayle R, Schauer GD, et al. (2017) Author response: Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks Elife |
Langston L, O’Donnell M. (2017) Author response: Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase Elife |
Bastia D, Srivastava P, Zaman S, et al. (2016) Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest. Proceedings of the National Academy of Sciences of the United States of America |
Georgescu RE, Schauer GD, Yao NY, et al. (2015) Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation. Elife. 4: e04988 |