Derek A. Debe, Ph.D.

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
Structure and function of membrane proteins
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"Derek Debe"
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SNBCP

Parents

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Sunney I. Chan grad student 2001 Caltech
 (Shaving Levinthal with Occam's razor: Understanding the rate limiting step in protein folding.)
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Publications

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Debe DA, Mamidipaka RB, Gregg RJ, et al. (2013) ALOHA: a novel probability fusion approach for scoring multi-parameter drug-likeness during the lead optimization stage of drug discovery. Journal of Computer-Aided Molecular Design. 27: 771-82
Poleksic A, Fienup M, Danzer JF, et al. (2008) A different look at the quality of modeled three-dimensional protein structures. Journal of Bioinformatics and Computational Biology. 6: 335-45
Muchmore SW, Debe DA, Metz JT, et al. (2008) Application of belief theory to similarity data fusion for use in analog searching and lead hopping. Journal of Chemical Information and Modeling. 48: 941-8
Hambly K, Danzer J, Muskal S, et al. (2006) Interrogating the druggable genome with structural informatics. Molecular Diversity. 10: 273-81
Poleksic A, Danzer JF, Palmer BA, et al. (2006) SPINFAST: using structure alignment profiles to enhance the accuracy and assess the reliability of protein side-chain modeling. Proteins. 65: 953-8
Palmer B, Danzer JF, Hambly K, et al. (2006) StructSorter: a method for continuously updating a comprehensive protein structure alignment database. Journal of Chemical Information and Modeling. 46: 1871-6
Debe DA, Danzer JF, Goddard WA, et al. (2006) STRUCTFAST: protein sequence remote homology detection and alignment using novel dynamic programming and profile-profile scoring. Proteins. 64: 960-7
Poleksic A, Danzer JF, Hambly K, et al. (2005) Convergent Island Statistics: a fast method for determining local alignment score significance. Bioinformatics (Oxford, England). 21: 2827-31
Debe DA, Hambly K. (2004) Supporting your pipeline with structural knowledge Current Drug Discovery. 15-18
Zhang D, Vaidehi N, Goddard WA, et al. (2002) Structure-based design of mutant Methanococcus jannaschii tyrosyl-tRNA synthetase for incorporation of O-methyl-L-tyrosine. Proceedings of the National Academy of Sciences of the United States of America. 99: 6579-84
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