Derek A. Debe, Ph.D.

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
Structure and function of membrane proteins
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"Derek Debe"
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Parents

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Sunney I. Chan grad student 2001 Caltech
 (Shaving Levinthal with Occam's razor: Understanding the rate limiting step in protein folding.)
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Publications

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Poleksic A, Fienup M, Danzer JF, et al. (2008) A different look at the quality of modeled three-dimensional protein structures. Journal of Bioinformatics and Computational Biology. 6: 335-45
Hambly K, Danzer J, Muskal S, et al. (2006) Interrogating the druggable genome with structural informatics. Molecular Diversity. 10: 273-81
Poleksic A, Danzer JF, Palmer BA, et al. (2006) SPINFAST: using structure alignment profiles to enhance the accuracy and assess the reliability of protein side-chain modeling. Proteins. 65: 953-8
Palmer B, Danzer JF, Hambly K, et al. (2006) StructSorter: a method for continuously updating a comprehensive protein structure alignment database. Journal of Chemical Information and Modeling. 46: 1871-6
Debe DA, Danzer JF, Goddard WA, et al. (2006) STRUCTFAST: protein sequence remote homology detection and alignment using novel dynamic programming and profile-profile scoring. Proteins. 64: 960-7
Zhang D, Vaidehi N, Goddard WA, et al. (2002) Structure-based design of mutant Methanococcus jannaschii tyrosyl-tRNA synthetase for incorporation of O-methyl-L-tyrosine. Proceedings of the National Academy of Sciences of the United States of America. 99: 6579-84
Debe DA, Goddard WA. (1999) First principles prediction of protein folding rates. Journal of Molecular Biology. 294: 619-25
Debe DA, Carlson MJ, Goddard WA. (1999) The topomer-sampling model of protein folding. Proceedings of the National Academy of Sciences of the United States of America. 96: 2596-601
Debe DA, Carlson MJ, Sadanobu J, et al. (1999) Protein Fold Determination from Sparse Distance Restraints: The Restrained Generic Protein Direct Monte Carlo Method Journal of Physical Chemistry B. 103: 3001-3008
Cavagnero S, Debe DA, Zhou ZH, et al. (1998) Kinetic role of electrostatic interactions in the unfolding of hyperthermophilic and mesophilic rubredoxins. Biochemistry. 37: 3369-76
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