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Jeffrey A. Pfefferkorn, Ph.D.

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
chemistry, biology, and medicine of natural and designed molecules
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"Jeffrey Pfefferkorn"
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K. C. Nicolaou grad student 2001 Scripps Institute
 (1. Total synthesis of sarcodictyins A and B and studies toward the synthesis of garsubellin A. 2. Design and solid phase synthesis of natural product like combinatorial libraries.)

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Publications

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Futatsugi K, Smith AC, Tu M, et al. (2020) Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose. Journal of Medicinal Chemistry
Huard K, Smith AC, Cappon GD, et al. (2020) Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase (ACC) Inhibitors Through Liver Targeting. Journal of Medicinal Chemistry
Esler WP, Tesz GJ, Hellerstein MK, et al. (2019) Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition. Science Translational Medicine. 11
Huard K, Ahn K, Amor PA, et al. (2017) Discovery of Fragment-Derived Small Molecules for In Vivo Inhibition of Ketohexokinase (KHK). Journal of Medicinal Chemistry
Ahn K, Brown MF, Boehm M, et al. (2016) Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism. Acs Chemical Biology
Huard K, Brown J, Jones JC, et al. (2015) Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5). Scientific Reports. 5: 17391
Futatsugi K, Kung DW, Orr ST, et al. (2015) Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). Journal of Medicinal Chemistry
Sharma R, Litchfield J, Bergman A, et al. (2015) Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 190-8
Lee EC, Tu M, Stevens BD, et al. (2014) Identification of a novel conformationally constrained glucagon receptor antagonist. Bioorganic & Medicinal Chemistry Letters. 24: 839-44
Borzilleri KA, Pfefferkorn JA, Guzman-Perez A, et al. (2014) Optimizing glucokinase activator binding kinetics to lower in vivo hypoglycemia risk Medchemcomm. 5: 802-804
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