Daniel M. Himmel, Ph.D.

Affiliations: 
Brandeis University, Waltham, MA, United States 
Area:
Protein Structure, Dynamics, and Assembly
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"Daniel Himmel"
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Carolyn Cohen grad student 2001 Brandeis
 (Structural studies on the myosin molecular motor: A. Evidence for a "detached" ATP site, and B. Comparison of calcium-bound and calcium-free regulatory domains.)
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Publications

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Himmel DM, Myshakina NS, Ilina T, et al. (2014) Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs. Journal of Molecular Biology. 426: 2617-31
Felts AK, Labarge K, Bauman JD, et al. (2011) Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies. Journal of Chemical Information and Modeling. 51: 1986-98
Chung S, Himmel DM, Jiang JK, et al. (2011) Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. Journal of Medicinal Chemistry. 54: 4462-73
Himmel DM, Maegley KA, Pauly TA, et al. (2009) Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Structure (London, England : 1993). 17: 1625-35
Himmel DM, Mui S, O'Neall-Hennessey E, et al. (2009) The on-off switch in regulated myosins: different triggers but related mechanisms. Journal of Molecular Biology. 394: 496-505
Bauman JD, Das K, Ho WC, et al. (2008) Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Research. 36: 5083-92
Knight JL, Zhou Z, Gallicchio E, et al. (2008) Exploring structural variability in X-ray crystallographic models using protein local optimization by torsion-angle sampling. Acta Crystallographica. Section D, Biological Crystallography. 64: 383-96
Himmel D, Pauly T, Bauman J, et al. (2008) Structure for an HIV-1 reverse transcriptase RNase H inhibitor bound at the active site Acta Crystallographica Section a Foundations of Crystallography. 64: C348-C348
Yang Y, Gourinath S, Kovács M, et al. (2007) Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor. Structure (London, England : 1993). 15: 553-64
Himmel DM, Sarafianos SG, Dharmasena S, et al. (2006) HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Acs Chemical Biology. 1: 702-12
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