Todd R. Ryder, Ph.D.

2006 University of Rochester, Rochester, NY 
Synthetic Organic Chemistry
"Todd Ryder"
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Robert K. Boeckman, Jr. grad student 2006 Rochester
 (1. Synthesis of a (+)-discodermolide analog. 2. Studies of (-)-nakadomarin A.)
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Boeckman RK, Wang H, Rugg KW, et al. (2016) A Scalable Total Synthesis of (-)-Nakadomarin A. Organic Letters. 18: 6136-6139
Golebiowski A, Whitehouse D, Beckett RP, et al. (2013) Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction. Bioorganic & Medicinal Chemistry Letters. 23: 4837-41
Van Zandt MC, Whitehouse DL, Golebiowski A, et al. (2013) Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. Journal of Medicinal Chemistry. 56: 2568-80
Golebiowski A, Paul Beckett R, Van Zandt M, et al. (2013) 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 2027-30
Boeckman RK, Miller Y, Ryder TR. (2010) Diels-Alder reactions of cyclic isoimidium salts. Organic Letters. 12: 4524-7
Boeckman RK, Genung NE, Chen K, et al. (2010) Synthetic and mechanistic studies of the aza-retro-Claisen rearrangement. A facile route to medium ring nitrogen heterocycles. Organic Letters. 12: 1628-31
Hu LY, Boxer PA, Kesten SR, et al. (2006) The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorganic & Medicinal Chemistry Letters. 16: 2337-40
Hu LY, Ryder TR, Rafferty MF, et al. (2000) Neuronal N-type calcium channel blockers: a series of 4-piperidinylaniline analogs with analgesic activity. Drug Design and Discovery. 17: 85-93
Hu LY, Ryder TR, Rafferty MF, et al. (2000) The discovery of [1-(4-dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phen yl]-(3-methyl-but-2-enyl)-amine, an N-type Ca+2 channel blocker with oral activity for analgesia. Bioorganic & Medicinal Chemistry. 8: 1203-12
Ryder TR, Hu LY, Rafferty MF, et al. (2000) Structure-activity relationship at the leucine side chain in a series of N,N-dialkyldipeptidyl-amines as N-type calcium channel blockers. Drug Design and Discovery. 16: 317-22
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